荔枝草咀嚼片配方工艺研究  

Research on the Formulation of Salvia plebeia Chewable Tablets

作　　者：钱俊[1] 曹苗苗[2,3] 徐桂红[2,3] 孔庆新[1] 李思阳[1] 赵琰玲 王敏 QIAN Jun;CAO Miao-miao;XU Gui-hong;KONG Qing-xin;LI Si-yang;ZHAO Yan-ling;WANG Min(Jiangsu Food and Pharmaceutical Science College, Huai'an 223003, China;Jiangsu Kanion Parmaeeutical Co., Ltd., Lianyungang 222001 ,China;State Key Laboratory of New-tech for Chinese Medicine Pharmaiceutical Process,Lianyungang 222001,China)

机构地区：[1]江苏食品药品职业技术学院,江苏淮安223003 [2]江苏康缘药业股份有限公司,江苏连云港222001 [3]中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《中药材》2018年第8期1941-1946,共6页Journal of Chinese Medicinal Materials

基　　金：江苏淮安市科技项目(HAG201613)

摘　　要：目的:优化荔枝草咀嚼片配方工艺。方法:以外观、风味、口感为评价指标,利用模糊数学和响应面法优化制剂配方,并对其品质进行评价。结果:最优配方为:荔枝草提取物∶甘露醇∶乳糖∶阿斯巴甜∶柠檬酸为100∶30∶10∶1∶1(质量比),制备的咀嚼片表面光滑,色泽均匀,酸甜爽口,片重差异、硬度、脆碎度等各项指标均符合咀嚼片相关要求。结论:优选的制备工艺稳定可行,可为荔枝草咀嚼片的规模化生产提供参考。Objective:To optimize the formulation of Salvia plebeia chewable tablets.Methods:The fuzzy mathematics and response surface test were used to optimize the formulation of Salvia plebeia chewable tablets with appearance,flavor and taste as three indicators,which quality was evaluated.Results:The optimized process parameter for chewable tablets was as follows:the content ratio of Salvia plebeia extract,mannitol,lactose,aspartame,citric acid was 100∶30∶10∶1∶1(mass ratio).Under this condition,the chewable tablets showed a smooth surface with uniform color,sweet and sour refreshing.The weight difference,hardness,crispness and other indexes accorded with the relevant requirements of chewable tablets.Conclusion:The optimized preparation process is stable and feasible,which provides an important reference for large-scale production of Salvia plebeia chewable tablets.

关 键 词：荔枝草 咀嚼片 模糊数学 响应面 BOX-BEHNKEN设计 

分 类 号：R283.6[医药卫生—中药学]