茶芎地上部分的化学成分研究  

Chemical Constituents from the Aerial Parts of Ligusticum sinense

作　　者：杨建波[1,2] 魏倩 王爱国 马双成 程显隆[1] 魏锋[1] YANG Jian-bo;WEI Qian;WANG Ai-guo;MA Shuang-cheng;CHENG Xian-long;WEI Feng(National Institutes for Food and Drug Control,Traditional Chinese Medicine Testing Institute,Beijing 100050,China;Slate KeyLaboratory of Bioactive Substance and Function of Natural Medicines,Instilute of Materia Medica,Chinese Academy of Medit al Sciencesand Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国食品药品检定研究院中药民族药检定所,北京100050 [2]中国医学科学院/北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中药材》2018年第10期2339-2342,共4页Journal of Chinese Medicinal Materials

基　　金：江西省重点研发计划项目(20171ACH80003);国家自然科学基金(81703665)

摘　　要：目的:研究茶芎Ligusticum sinense Oliv.cv.Chaxiong地上部分的化学成分。方法:采用薄层色谱、D101型大孔吸附树脂树脂、Sephadex LH-20凝胶柱色谱等方法进行分离纯化,使用波谱分析技术和理化常数对照等方法对得到的化合物进行结构鉴定。结果:从茶芎地上部分的正丁醇部位中分离得到3个咖啡酰基奎尼酸类和5个黄酮类化合物,分别鉴定为:5-O-(6′-甲氧基)咖啡酰奎尼酸丁酯(1)、5-O-咖啡酰基奎宁酸丁酯(2)、4-O-咖啡酰基奎尼酸丁酯(3)、三叶豆苷(4)、槲皮素-3′-甲氧基-3-O-β-D-半乳糖苷(5)、槲皮素-3-O-β-D-半乳糖苷(6)、6″-O-乙酰金丝桃苷(7)、槲皮素(8)。结论:化合物1～8均为首次从该植物分离得到。Objective:To investigate the chemical constituents from the aerial parts of Ligusticum sinense.Methods:The chemical constituents were isolated and purified by silical gel,macroporous resin(D101)and Sephadex LH-20.Their structures were elucidated based on the spectrum analysis and comparison of physical constan.Results:Three caffeoylquinic acid compounds and five flavonoids were isolated and identified as 5-O-(6′-methoxyl)quinic acid butyl ester(1),5-O-caffeoylquinic acid butyl ester(2),4-O-caffeoylquinic acid butyl ester(3),trifolin(4),quercetin 3′-methoxyl-3-O-β-D-galactopyranoside(5),quercetin-3-O-β-D-galactopyranoside(6),6″-O-acetylhyperoside(7),quercetin(8).Conclusion:Compound 1~8 are isolated from this plant for the first time.

关 键 词：茶芎 化学成分 咖啡酰基奎尼酸类化合物 黄酮类化合物 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]