地榆正丁醇部位化学成分研究  

Chemical Constituents of n-Butanol Extract from Sanguisorba officinalis

作　　者：王丽娜[1] 韩雪花[1] 李小华 邱玲[1] 李莎[1] 邓赟[1] WANG Lima;HAN Xue-hua;LI Xiao-hua;QIU Ling;LI Slia;DENG Yun(Pharmacy College,Chengdu University of fradilional Chinese Medicine,The Ministry of Education Key Laboralory of Standardization of Chinese Herbal Medicine, Breeding Base of Skite Key laboratory of Scientific Research citid Exploitation of Traditional Chinese Medicine Resources,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室/中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137

出　　处：《中药材》2018年第9期2108-2111,共4页Journal of Chinese Medicinal Materials

基　　金：国家科技部新药创制重大专项中药大品种技术改造与技术提升研究(地榆生白片技术改造)(2014ZX09201021-008);中药药效物质基础研究与创新中药发现四川省青年科技创新研究团队(2016TD0006);四川省科技厅支撑计划项目中药种质资源库建设关键技术研究及示范(2014SZ0156)

摘　　要：目的:研究地榆正丁醇部位的化学成分。方法:运用大孔树脂、Toyopearl HW-40、反相硅胶等柱色谱法对地榆正丁醇部位进行分离纯化,并运用波谱方法对化合物进行结构鉴定。结果:从地榆正丁醇部位中分离并鉴定了13个化合物,分别为:3,4-dihydroxy-5-methoxy-benzoic acid ethyl ester(1)、p-styryl-O-β-D-xylosyl-(1-6)-O-β-D-glucopyranoside(2)、geranyl-1-O-β-D-xylopyranosyl-(1-6)-β-D-glucopyranoside(3)、prunin(4)、confusoside(5)、garbanzol(6)、icariside E4(7)、p-hydroxybenzoic acid(8)、altenuisol(9)、4-(2-propen-1-yl)phenyl-β-D-glucopyranoside(10)、2,7-dimethyl-2,6-octadiene-1,8-diol(11)、1-phenyl-1,2-ethanediol(12)、methyl-3,5-dihydroxy-4-methoxybenzoate(13)。结论:其中,化合物1～7和9～13均为首次从该植物中分离得到。Objective:To study the chemical constituents of n-butanol extract from Sanguisorba officinalis.Methods:Compounds were isolated from n-butanol extract by chromatographic methods of macroporous resin(D101,HP-20),Toyopearl HW-40 and reversed phase silica gel columns.And structures were identified by spectroscopic evidence.Results:Thirteen compounds were isolated and their structures were elucidated as 3,4-dihydroxy-5-methoxy-benzoic acid ethyl ester(1),p-styryl-O-β-D-xylosyl-(1-6)-O-β-D-glucopyranoside(2),geranyl-1-O-β-D-xylopyranosyl-(1-6)-β-D-glucopyranoside(3),prunin(4),confusoside(5),garbanzol(6),icariside E4(7),p-hydroxybenzoic acid(8),altenuisol(9),4-(2-propen-1-yl)phenyl-β-D-glucopyranoside(10),2,7-dimethyl-2,6-octadiene-1,8-diol(11),1-phenyl-1,2-ethanediol(12),methyl-3,5-dihydroxy-4-methoxybenzoate(13).Conclusion:Compounds 1~7 and 9~13 are isolated from this plant for the first time.

关 键 词：地榆 正丁醇部位 结构鉴定 

分 类 号：K284.1[历史地理—历史学] R284.2[历史地理—中国史]