自乳化释药系统对丹参酮类多组分增溶作用的研究  

Solubilization of Self-Emulsifying Drug Delivery System for Tanshinone Muticomponents

作　　者：柯秀梅[1,2] 徐良贤[2] 黄浩洲 张定堃[1] 韩丽[1] 余文敏[2] 刘频健[2] KE Xiu-mei;XU Liang-xian;HUANG Hao-zhou;ZHANG Ding-kun;HAN Li;YU Wen-min;LIU Pin-jian(Pharmacy College,Chengdu University of Traditional Chinese Medicine,Key Laboratory Breeding Base of Systematic Research and Utilizcition on Chinese Material Medical Krsourcrs Co-founded by Sichuan Province and Ministry of Science and Technology ,Chengdu 611137,China;Basic Medical College of Jiujiang University,Key Laboratoiy of Translational Medicine,Jiujiang 332000,China)

机构地区：[1]成都中医药大学药学院/中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137 [2]九江学院基础医学院/九江市转化医学重点实验室,江西九江332000

出　　处：《中药材》2018年第12期2871-2875,共5页Journal of Chinese Medicinal Materials

基　　金：江西省科技厅项目(20181BAB215040);江西省卫生厅项目(20173020).

摘　　要：目的:探讨自乳化释药系统(SEDDS)对丹参酮类组分增溶的效果。方法:采用D-最优混料设计优化SEDDS处方,以隐丹参酮、丹参酮Ⅰ和丹参酮Ⅱ_A含量、SEDDS的粒径和乳化时间为指标对SEDDS进行优化并对其进行综合评价。结果:优化得SEDDS最佳处方为:油酸∶吐温-20∶二乙二醇单乙基醚(0.25∶0.52∶0.23),SEDDS粒径为(204±5)nm,乳化时间为(59±2)s。37℃时,SEDDS对隐丹参酮、丹参酮Ⅰ和丹参酮Ⅱ_A的最大载药量分别为5.075、3.397和6.559 mg/g,在水中的溶解度分别为0.138、0.238和0.367 mg/mL。结论:SEDDS对丹参酮类组分的增溶效果显著。Objective:To explore the solubilization of self-emulsifying drug delivery system(SEDDS)for tanshinone muticomponents.Methods:With D-optimal mixture design to optimize SEDDS prescription,the contents of cryptotanshinone,tanshinone Ⅰ,tanshinone ⅡA and SEDDS particle size,emulsifying time were used as indicators to select and evaluate SEDDS.Results:The best SEDDS prescription was oleic acid∶Tween 20∶transcutol p(0.25∶0.52∶0.23),SEDDS particle size was(204±5)nm,emulsifying time was(59±2)s.At 37 ℃,the maximum loading capacities of SEDDS for cryptotanshinone,tanshinoneⅠ and tanshinone ⅡA were 5.075,3.397 and 6.559 mg/g,solubilities in water were 0.138,0.238 and 0.367 mg/mL,respectively.Conclusion:SEDDS can realize the solubilization of tanshinone muticomponents obviously.

关 键 词：自乳化释药系统 增溶 丹参酮 组分 D-最优混料设计 

分 类 号：R283.6[医药卫生—中药学]