小剂量凝血因子输注治疗血友病急性关节出血的疗效分析  

Efficacy analysis of low-dose coagulation factor infusion on acute joint bleeding in hemophilia

作　　者：陈敏[1] CHEN Min(Shandong Blood Center,Ji' nan 250014,China)

机构地区：[1]山东省血液中心,250014

出　　处：《中国实用医药》2019年第14期13-15,共3页China Practical Medicine

摘　　要：目的分析小剂量凝血因子输注治疗血友病急性关节出血的疗效。方法 85例血友病急性关节出血患儿,均行小剂量凝血因子输注治疗。比较治疗前、治疗后1年出血程度、视觉模拟评分法(VAS)评分、生活质量。结果治疗后,患儿出血程度显著优于治疗前,差异具有统计学意义(P<0.05)。治疗后,患儿VAS评分为(1.15±0.11)分,显著低于治疗前的(3.26±0.68)分,差异具有统计学意义(P<0.05)。治疗后,患儿环境、社会、心理、生理生活质量评分分别为(89.62±6.84)、(91.52±7.14)、(91.48±7.09)、(90.05±7.01)分,均显著高于治疗前的(62.85±5.14)、(61.05±5.08)、(63.74±5.34)、(62.89±5.16)分,差异均具有统计学意义(P<0.05)。结论小剂量凝血因子输注可有效减轻血友病急性关节出血患儿出血情况与疼痛程度,提升生活质量,效果显著,值得借鉴。Objective To analyze the efficacy of low-dose coagulation factor infusion on acute joint bleeding in hemophilia. Methods A total of 85 hemophilia children with acute joint bleeding all were treated with low-dose coagulation factor infusion. The bleeding degree, visual analogue scale(VAS) score and quality of life were compared before treatment and 1 year after treatment. Results Patients had significantly better bleeding degree after treatment than those before treatment, and the difference was statistically significant(P<0.05). After treatment, patients had significantly lower VAS score as(1.15±0.11) points than(3.26±0.68) points before treatment, and the difference was statistically significant(P<0.05). After treatment, patients had significantly higher environmental, social, psychological and physiological quality of life score respectively as(89.62±6.84),(91.52±7.14),(91.48±7.09) and(90.05±7.01) points than(62.85±5.14),(61.05±5.08),(63.74±5.34) and(62.89±5.16) points before treatment, and their difference was statistically significant(P<0.05). Conclusion Low-dose coagulation factor infusion shows remarkable effect in effectively reducing bleeding and pain degree of hemophilia children with acute joint bleeding and improving quality of life. It is worthy of reference.

关 键 词：小剂量凝血因子输注 血友病 急性关节出血 疗效 

分 类 号：R554.1[医药卫生—血液循环系统疾病]