基质金属蛋白酶-8与肺结核复发的相关性研究  

Study on the correlation between matrix metalloproteinase-8 and recurrence of tuberculosis

作　　者：陈伊[1] 翁琼琳[1] 邓君丽[1] CHEN Yi;WENG Qiong-lin;DENG Jun-li(Shenzhen Baoan District Chronic Disease Prevention and Treatment Institute,Shenzhen. 518000,China)

机构地区：[1]深圳市宝安区慢性病防治院,518000

出　　处：《中国实用医药》2019年第14期41-43,共3页China Practical Medicine

基　　金：2017年深圳市宝安区医疗卫生基础研究项目(项目编号:2017JD168)

摘　　要：目的探讨基质金属蛋白酶-8(MMP-8)与肺结核复发的相关性及评估其临床价值。方法选取初治活动性肺结核患者86例(初治活动性肺结核组)、复发肺结核患者46例(复发肺结核组)、健康体检者56例(健康对照组),采用酶联免疫吸附实验(ELISA)法检测三组的血清MMP-8浓度,并作比较,分析复发肺结核患者的诊断临界值、敏感度、特异度。结果初治活动性肺结核组的血清MMP-8浓度高于健康对照组,差异有统计学意义(Z=-8.145, P=0.000<0.05)。复发肺结核组的血清MMP-8浓度高于健康对照组,差异有统计学意义(Z=-6.528, P=0.000<0.05)。初治活动性肺结核组与复发肺结核组的血清MMP-8浓度比较差异无统计学意义(Z=-0.236, P=0.813>0.05)。根据复发肺结核组及健康对照组血清MMP-8浓度绘制受试者工作特征曲线(ROC)曲线,得出复发肺结核患者的诊断临界值为1.88 ng/ml、敏感度为91.3%和特异度为69.6%。表明血清MMP-8浓度在复发肺结核的诊断中有一定的准确度[曲线下面积(AUC)=0.875, 95%CI=(0.811, 0.940), P=0.000<0.05]。结论 MMP-8与肺结核复发有一定的相关性并具有一定的临床价值。Objective To discuss the correlation between matrix metalloproteinase-8(MMP-8) and recurrence of tuberculosis and evaluate its clinical value. Methods 86 patients with newly diagnosed active pulmonary tuberculosis(initial active pulmonary tuberculosis group), 46 patients with recurrent pulmonary tuberculosis(recurrent pulmonary tuberculosis group), and 56 healthy subjects(healthy control group) were selected. The serum MMP-8 concentrations of the three groups were tested by enzyme-linked immunosorbent assay(ELISA) and compared to analyze the diagnostic threshold, sensitivity and specificity of patients with recurrent pulmonary tuberculosis. Results Initial active pulmonary tuberculosis group had higher concentrations of serum MMP-8 than healthy control group, and the difference was statistically significant(Z=-8.145, P=0.000<0.05).Recurrent pulmonary tuberculosis group had higher concentrations of serum MMP-8 than healthy control group,and the difference was statistically significant(Z=-6.528, P=0.000<0.05). Initial active pulmonary tuberculosis group and recurrent pulmonary tuberculosis group had no statistically significant in concentrations of serum MMP-8(Z=-0.236, P=0.813>0.05). The receiver operating characteristic(ROC) curve was drawn according to the serum MMP-8 concentration in the recurrent pulmonary tuberculosis group and the healthy control group. The diagnostic threshold, sensitivity and specificity of patients with recurrent pulmonary tuberculosis were 1.88 ng/ml,91.3% and 69.6% respectively. The serum MMP-8 concentration showed a certain degree of accuracy in the diagnosis of recurrent pulmonary tuberculosis [area under curve(AUC)=0.875, 95%CI=(0.811, 0.940), P=0.000<0.05].Conclusion MMP-8 is related to the recurrence of pulmonary tuberculosis and has certain clinical value.

关 键 词：基质金属蛋白酶-8 肺结核 复发 

分 类 号：R521[医药卫生—内科学]