血清C1q、CTRP1与冠状动脉粥样硬化性心脏病的相关性研究  

Correlation between serum C1q, CTRP1 and coronary atherosclerotic heart disease

作　　者：林文婷[1] 曾敏[1] 陈积雄[1] 何扬利[1] 蒙绪卿[1] 符秀虹[1] 符武岛 徐文星[1] Lin Wenting;Zeng Min;Chen Jixiong;He Yangli;Meng Xuqing;Fu Xiuhong;Fu Wudao;Xu Wenxing(Hainan General Hospital,Haikou 570311,China)

机构地区：[1]海南省人民医院

出　　处：《中国循证心血管医学杂志》2019年第5期534-536,540,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：2017国家自然科学基金地区基金项目(81760054);2014年海南省重点科技计划项目(ZDXM2014065)

摘　　要：目的探讨血清C1q、补体C1q肿瘤坏死因子相关蛋白1(CTRP1)与冠状动脉粥样硬化性心脏病(冠心病,CHD)的相关性。方法选取2017年1月至2018年1月收治于海南省人民医院的113例CHD患者作为冠心病组,另选取同期冠状动脉管腔狭窄小于50%的非CHD患者100例作为对照组,检测各组患者的空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、CTRP1和C1q水平,并应用多因素Logistic回归分析其与CHD的关系。结果冠心病组吸烟、高血压、糖尿病比例显著高于对照组,数据差异具有统计学意义(P<0.05)。冠心病组患者HDL-C水平显著低于对照组,而TC、LDL-C、FBG均显著高于对照组,差异具有统计学意义(P<0.05)。冠心病组患者的血清C1q水平显著低于对照组,而血清CTRP1水平则显著高于对照组,差异有统计学意义(P<0.05)。高血压、糖尿病、TC≥4.32mmol/L、LDL-C≥2.52mmol/L,C1q≤172.37ng/L,CTRP1≥8.28ng/L是冠心病发病的危险因素(P<0.05),HDL-C≥1.10mmol/L是冠心病发病的保护性因素(P<0.05)。结论血清C1q、CTRP1水平与冠心病的发生、发展密切相关,可作为冠心病早期诊治及预后判断的定期筛选及监测指标。Objective To investigate the correlation between serum C1q,complement-Clq TNF-related protein 1(CTRP1)and coronary atherosclerotic heart disease (CHD). Methods A total of 113 patients with CHD admitted to Hainan General Hospital from January 2017 to January 2018 were enrolled as the CHD group. 100 non- CHD patients with coronary stenosis less than 50% were selected as control group. The level of fasting blood glucose (FBG),total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),CTRP1 and C1q was measured. Multivariate Logistic regression analysis was used to analyze the relationship between the above indicators and CHD. Results The proportion of smoking,hypertension,diabetes in CHD group was significantly higher than that in control group,and the difference was statistically significant (P <0.05). The level of HDL-C in CHD group was significantly lower than that in the control group,while the level of TC,LDL-C,FBG was significantly higher than that in the control group (P<0.05). The serum C1q level of patients with CHD was significantly lower than that of the control group,while the serum CTRP1 level was significantly higher than that of the control group,with a statistically significant difference (P<0.05). Hypertension,diabetes, TC≥4.32 mmol/L,LDL-C≥2.52 mmol/L,C1q<172.37 ng/L,CTRP1≥8.28 ng/L was the risk factor of CHD (P <0.05),HDL-C≥1.10 mmol/L was the protective factor of CHD. Conclusion The level of serum C1q and CTRP1 is closely related to the occurrence and development of CHD. It can be used as a regular screening and monitoring indicator for early diagnosis and prognosis of CHD.

关 键 词：血清C1q CTRP1 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]