1例利奈唑胺个体化给药案例报道  

A case report of linezolid individualized administration

作　　者：郑亮[1] 白浩[2] 徐文俊[3] 方洁[4] ZHENG Liang;BAI Hao;XU Wenjun;FANG Jie(Department of Pharmacy, the Central People’s Hospital of Zhanjiang, Guangdong Zhanjiang 524045, China;Department of Pharmacy, Chongqing Cancer Hospital, Chongqing 400030, China;Department of Pharmacy, Northern Jiangsu People's Hospital, Jiangsu Yangzhou 225001, China;Department of Pharmacy, Ruijin Hospital affiliated to the School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China)

机构地区：[1]广东省湛江中心人民医院药剂科,广东湛江524045 [2]重庆市肿瘤医院药剂科,重庆400030 [3]江苏省苏北人民医院药剂科,江苏扬州225001 [4]上海交通大学医学院附属瑞金医院药剂科,上海200025

出　　处：《上海医药》2019年第11期56-60,共5页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨利奈唑胺个体化给药治疗策略,为优化利奈唑胺给药方案积累经验。方法:临床药师参与1例高龄伴急性肾功能不全的耐甲氧西林金黄色葡萄球菌肺炎患者的治疗,在患者使用标准剂量的利奈唑胺治疗出现血小板下降时,运用治疗药物监测,协助临床医师优化抗感染治疗方案,并对患者的初始给药方案选择、后续方案调整、疗效观察和不良反应监测等方面进行药学监护。结果:根据血药浓度监测,调整药物的剂量,患者感染得到有效控制,血小板恢复正常。结论:临床药师作为临床团队一员,应充分运用药学知识结构特长,根据患者的情况,制定合理的治疗方案,并观察药物疗效,监测不良反应,保证药物治疗安全、经济、有效、合理。Objective: To discuss the treatment strategy of individualized administration of linezolid so as to accumulate clinical experience for the optimization of the linezolid dosage regimen. Methods: The clinical pharmacists participated in the treatment of an elderly patient with pneumonia by methicillin-resistant Staphylococcus aureus complicated with acute renal insufficiency. In case platelet count decreased when standard doses of linezolid was given, the pharmacist assisted clinicians in optimizing anti-infective treatment regimens by the monitoring of medication and meanwhile perform pharmaceutical care in several aspects such as initial dosing options, follow-up therapy adjustments, efficacy observations and adverse reaction monitoring. Results: The infection was effectively controlled by dose adjustment of the antibiotics according to the monitoring of therapeutic drug. Conclusion: As a member of the clinical team, clinical pharmacists should make full use of their pharmacy knowledge, develop a reasonable treatment regime according to the patient’s situation, observe the drug efficacy and monitor adverse reactions so as to ensure that the drug treatment is safe, economical, effective and reasonable.

关 键 词：利奈唑胺 血小板下降 血药浓度监测 个体化给药 

分 类 号：R978.19[医药卫生—药品] R969.3[医药卫生—药学]