新精神活性物质的三维荧光光谱检测方法研究  

Determination of New Psychoactive Substances by Their Three-dimensional Fluorescence

作　　者：徐布一 蒋和平[1] 黄浩东[2] 王周丽 王燕军[2] XU Buyi;JIANG Heping;HUANG Haodong;WANG Zhouli;WANG Yanjun(Sichuan Police College,Luzhou 646000,Sichuan,China;Sichuan Provincial Department of Public Security,Chengdu 610041,China)

机构地区：[1]四川警察学院,四川泸州646000 [2]四川省公安厅,成都610041

出　　处：《刑事技术》2019年第3期224-227,共4页Forensic Science and Technology

摘　　要：新精神活性物质的合成和滥用问题日益严峻。本文提出将三维荧光光谱法用于4种常见新精神活性物质快速检测分析。结果表明,2,5-二甲氧基苯乙胺(2C-H)、3,4-亚甲基二氧甲基卡西酮(MDMC)、亚甲基二氧吡咯戊酮(MDPV)和氯胺酮有不同的荧光光谱特征,荧光强度最大处的荧光峰位置(λex/λem)分别为284/326、282/430、282/430、270/392nm。2C-H荧光分析法灵敏度最高,氯胺酮的灵敏度最低。在尿样内源荧光物质干扰下,利用三维荧光光谱法与平行因子算法相结合提取新精神活性物质的荧光信号,解析出的激发光谱和发射光谱与标准品的实测光谱较为一致,样品添加回收率范围为91.3%~111.2%。New psychoactive substances (NPS) are increasing to be a grim problem with their synthesis and abuse.Here, three-dimensional fluorescent spectroscopy was proposed for rapid determination of four typical new psychoactive substances (2,5-dimethoxyphenethylamine or 2C-H,3,4-methylenedioxy-N-methylcathinone or MDMC,methylenedioxypyrovalerone or MDPV,and ketamine).Results showed that the fluorescent characteristics of the interested substances were different,the peak maximal fluorescence intensity (λex/λem) appeared at 284/326,282/430,282/430 and 270/392nm for 2C-H,MDMC,MDPV and ketamine,respectively,with 2C-H being most sensitive yet ketamine lowest sensitivity.Deducted of the interference from the fluorescent substance in urine,the fluorescence signals of the interested NPS were extracted with parallel factor analysis (PARAFAC) into each three-dimensional fluorescence.The PARAFAC-resolved fluorescent spectra of the four typical NPS in urine were consistent with those of the standard reference materials,with the recoveries among the range of 91.3%~111.2%.

关 键 词：新精神活性物质 三维荧光 平行因子 

分 类 号：DF795.1[医药卫生—法医学]