清热利湿方联合1%吡美莫司乳膏治疗面部脂溢性皮炎疗效观察  

Efficacy of Qingre Lishi Recipe Combined with 1% Pimecrilimus Cream in the Treatment of Facial Seborrheic Dermatitis

作　　者：艾平 李慧 张洋 吕君 AI Ping;LI Hui;ZHANG Yang;LV Jun(Department of Dermatology,Affiliated Minda Hospital of Hubei Institute for Nationalities,Enshi 445000,Hubei,China;Dermatological Disease Treatment Center,the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi445000,Hubei,China)

机构地区：[1]湖北民族学院附属民大医院皮肤科,湖北恩施445000 [2]恩施土家族苗族自治州中心医院皮肤性病诊疗中心,湖北恩施445000

出　　处：《中国美容医学》2019年第6期47-51,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨清热利湿方联合1%吡美莫司乳膏治疗面部脂溢性皮炎的临床疗效。方法:选择2015年5月-2017年12月湖北民族学院附属民大医院和恩施土家族苗族自治州中心医院共同收治的面部脂溢性皮炎患者146例,按照随机数字表法,分为对照组(n=73)和观察组(n=73)。对照组外用1%吡美莫司乳膏进行治疗,观察组在对照组基础上联合使用清热利湿方进行治疗。两组患者连续治疗4周。比较治疗后临床总有效率及治疗前后皮肤生理指标[皮肤含水量、经表皮失水量(TEWL)、皮脂分泌率和pH值。分别于治疗前(T0)、治疗后1周(T1)、2周(T2)和4周(T3)检测患者血清组织蛋白酶S(CatS)水平,对比两组不良反应发生率和复发率。结果:观察组治疗后临床总有效率为84.93%,明显高于对照组的49.32%,差异有统计学意义(P<0.05);两组患者治疗后皮肤含水量明显高于治疗前,而TEWL和皮脂分泌率显著低于治疗前,同时观察组治疗后各项皮肤生理参数改善情况均明显优于对照组,差异均有统计学意义(P<0.05);与T0相比,两组患者T1、T2和T3时血清Cat S水平均明显下降,且观察组治疗后各时间点血清Cat S水平均显著低于对照组,差异有统计学意义(P<0.05);随着治疗时间的延长,两组患者血清Cat S水平显著下降(P<0.05);两组患者不良反应发生率和复发率比较差异无统计学意义(P>0.05)。结论:清热利湿方联合1%吡美莫司乳膏治疗面脂溢性皮炎疗效显著,能有效改善患者皮肤生理参数及血清Cat S水平,安全性高、复发率低,值得临床推广应用。Objective To explore the clinical efficacy of recipe for Qingre Lishi combined with 1% pimecrilimus cream on seborrheic dermatitis. Methods According to the random number table, 146 cases of patients admitted to the dermatology department of our hospital from May 2015 to December 2017 were divided into control group(n=73) and study group(n=73).Patients in the control group were treated with 1% pimecrilimus cream, while those in the study group were treated with recipe for Qingre Lishi on the basis of the control group. Two groups of patients were treated for 4 weeks. The clinical total effective rate of two groups of patients after treatment was compared. At the same time the skin physiology index[skin water content, the epidermal water loss(TEWL), sebum secretion rate and pH value] of two groups before and after treatment were compared.Moreover, the level of serum cathepsin S(Cat S) in patients was detected respectively before(T0), 1 week after the treatment(T1), 2 weeks(T2) and 4 weeks(T3). In addition, the adverse reactions incidence and recurrence rate of two groups of patients were compared. Results The total clinical efficiency of the study group was 84.93%, which was significantly higher than the 49.32% of the control group, and the difference was statistically significant(P<0.05). After treatment, the skin moisture content of the two groups was significantly higher than that of before treatment, while the TEWL and sebum secretion rate were significantly lower than those of before treatment. Meanwhile, the improvement of various skin physiological parameters of the study group was significantly better than that of the control group, and the differences were statistically significant(P<0.05).Compared with T0, the serum Cat S levels of both groups at T1, T2 and T3 significantly decreased, while the serum Cat S levels of the study group were significantly lower than those of the control group at all time points after treatment, and the differences were statistically significant(P<0.05). Meanwhile, the serum C

关 键 词：清热利湿方 吡美莫司乳膏 脂溢性皮炎 生理指标 临床疗效 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]