丹红注射液对体外循环下冠状动脉搭桥术患者的脑保护作用  

Protective effects of Danhong injection on brain protection undergoing coronary artery bypass graft under extracorporeal circulation

作　　者：但家朋[1] 张鲲[1] 王力甚[1] 朱冠华[1] 龚晓丹[1] 李德占[1] DAN Jia-peng;ZHANG Kun;WANG Li-shen;ZHU Guan-hua;GONG Xiao-dan;LI De-zhan(Department of Anesthesia,Jingzhou Central Hospital,Hubei,Jingzhou 434020,China)

机构地区：[1]荆州市中心医院麻醉科

出　　处：《中国医学前沿杂志（电子版）》2019年第6期87-90,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：2017—2018年度湖北省卫生计生委面上项目(WJ2017M242)

摘　　要：目的探讨丹红注射液对体外循环下冠状动脉搭桥术患者的脑保护作用。方法选取2016年1月至2017年5月在本院接受择期体外循环下冠状动脉搭桥术的患者48例,根据随机数表法将其分为对照组和观察组,每组各24例。观察组患者在预充以及开放主动脉时泵入丹红注射液1.5 ml/kg,对照组患者接受同等剂量的生理盐水。比较两组患者体外循环时间、主动脉阻断时间、手术时间、清醒时间以及手术开始前(T1)、复温至36℃时(T2)、停体外循环后30 min(T3)、停体外循环后6 h(T4)超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、肿瘤坏死因子-α(tumornecrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)、白细胞介素-10(interleukin-10,IL-10)水平变化。结果观察组患者清醒时间显著短于对照组(P<0.05),T2、T3、T4时间点血浆SOD水平均显著高于同期对照组(均P<0.05),血浆MDA水平均显著低于同期对照组(均P<0.05),T3、T4时间点TNF-α、IL-6、IL-8水平均显著低于同期对照组(均P<0.05),T4时间点IL-10水平显著高于同期对照组(P<0.05)。结论丹红注射液对体外循环下冠状动脉搭桥手术患者具有显著的脑保护作用。Objective To investigate the protective effect of Danhong injection on brain protection undergoing coronary artery bypass graft under extracorporeal circulation.Method From January 2016 to May 2017,48 cases of underwent elective extracorporeal circulation coronary artery bypass graft in our hospital were selected.According to the random number method,they were divided into control group and observation group with 24 cases each.Observation group patients were pumped with Danhong injection 1.5 ml/kg during pre-filling and open aorta,and control group patients received the same dose of normal saline.The extracorporeal circulation time,aortic occlusion time,operation time and awake time were compared between the two groups.The changes of superoxide dismutase (SOD),malondialdehyde (MDA),tumor necrosis factor-α(TNF-α),interleukin-6 (IL-6),interle ukin-8 (IL-8) and interleukin-10 (IL-10) at before surgery (T1),rewarming to 36℃(T2),30 min after cardiopulmonary bypass (T3),and 6 h after cardiopulmonary bypass (T4) were compared between the two groups.Result The awake time of observation group was significantly shorter than that of control group (P < 0.05).The levels of plasma SOD at the T2,T3 and T4 time points of observation group were significantly higher than those in control group (all P < 0.05),and the plasma MDA levels were significantly lower than those in control group (all P < 0.05).The levels of TNF-α,IL-6 and IL-8 at the T3 and T4 time points of observation group were significantly lower than those in control group (all P < 0.05).The level of IL-10 at the T4 time points of observation group was significantly higher than that in control group (P < 0.05).Conclusion Danhong injection has significant brain protection effect on patients undergoing coronary artery bypass graft under extracorporeal circulation.

关 键 词：丹红注射液 体外循环 冠状动脉搭桥术 脑保护 

分 类 号：R654.2[医药卫生—外科学]