星形胶质细胞在三方突触中对突触信息的加工处理和调控作用  

Role of astrocytes in controlling synaptic information in tripartite synapses

作　　者：郭航 马亚群 李海红[1] 马丽[1] 卢彦 王筱君 马玉龙 Guo Hang;Ma Yaqun;Li Haihong;Ma Li;Lu Yan;Wang Xiaojun;Ma Yulong(Department of Anesthesiology,The Seventh Medical Center,The PLA General Hospital,Beijing 100700,China;Department of Anesthesiology,The First Medical Center,The PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第七医学中心麻醉科,北京100700 [2]解放军总医院第一医学中心麻醉科,北京100853

出　　处：《中华神经创伤外科电子杂志》2019年第3期182-185,共4页Chinese Journal Of Neurotraumatic Surgery：Electronic Edition

基　　金：国家自然科学青年基金(8171072)

摘　　要：传统观念认为脑组织功能专属于神经元活动,最新研究表明除了经典的突触前、后神经元之间存在“双向”信息流之外,星形胶质细胞也参与突触的神经元间信息交换、对突触活性做出反应、调节突触传递等过程。本文将对星形角质细胞在突触生理学中的作用,就其整合和加工处理突触信息并通过释放胶质递质最终调节突触传递和可塑性综述如下。Traditionally,brain function is considered to be exclusive to neuronal activity. Recent studies have shown that in addition to the classical “bidirectional” information flow between presynaptic and postsynaptic neurons,astrocytes also participate in the process of information exchange between synaptic neurons,response to synaptic activity,and regulation of synaptic transmission. We review herein astrocytes integrate and process synaptic information and finally regulate synaptic transmission and plasticity through releasing gliotransmitters.

关 键 词：三方突触 星形胶质细胞 突触传递 突触可塑性 

分 类 号：R338[医药卫生—人体生理学]