早产儿真菌败血症的诊疗进展  

Advances in Diagnosis and Treatment of Fungal Septicemia in Premature Infants

作　　者：杨立颖[1] 马建荣[1] YANG Liying;MA Jianrong(Department of Neonatal Intensive Care Unit,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing100026,China)

机构地区：[1]首都医科大学附属北京妇产医院新生儿重症监护病房

出　　处：《医学综述》2019年第10期1980-1984,1989,共6页Medical Recapitulate

摘　　要：近年来随着围生医学的进步,越来越多的早产儿得到有效治疗。但由于早产儿自身及外界影响,真菌败血症的发生率也呈升高趋势,目前早产儿病原菌仍以念珠菌为主。真菌败血症严重影响了早产儿的生命及预后,其临床表现无特异性,血培养阳性是诊断的金标准,因此积极研究真菌感染早期的诊断方法,提高诊断的准确性和敏感性显得尤为重要。目前,氟康唑是治疗及预防早产儿真菌败血症的常用药物。未来,应进一步研究早产儿真菌感染预防药物的具体方案,合理安全使用抗真菌药物,以改善早产儿的预后,降低死亡率。In recent years, with the progress of perinatal medicine,more and more premature infants have been treated effectively.However,due to premature infants themselves and external influence,the incidence of fungal septicemia is also on the rise.Currently, Candida is still the main pathogen of fungal sepsis.Fungal septicemia seriously affects the life and prognosis of the premature infants.Its clinical manifestations are not specific.Positive blood culture is the golden standard for the diagnosis.Therefore,it is particularly important to actively study the early diagnosis methods of fungal infection and improve the accuracy and sensitivity of the diagnosis.At present,fluconazole is a commonly used drug for the treatment and prevention of fungal septicemia in premature infants.In the future,it is necessary to further study the specific medication schemes of fungal infection prevention,rationally and safely use antifungal drugs,in order to improve the prognosis and reduce the mortality.

关 键 词：真菌败血症 早产儿 念珠菌 感染 

分 类 号：R722.6[医药卫生—儿科]