血液灌流联合纳洛酮抢救安眠药中毒临床研究  

Clinical Study on Blood Perfusion Combined with Naloxone for Rescuing Patients with Hypnotic Poisoning

作　　者：蒋思源[1] 柯伟 张馥 曾伯石 陈玲 李琴[1] JIANG Siyuan;KE Wei;ZHANG Fu;ZENG Boshi;CHEN Ling;LI Qin(Xiaogan Central Hospital,Xiaogan,Hubei,China 432000;Hubei Zhongshan Hospital,Wuhan,Hubei,China 430030)

机构地区：[1]湖北省孝感市中心医院,湖北孝感432000 [2]湖北省中山医院,湖北武汉430030

出　　处：《中国药业》2019年第11期84-87,共4页China Pharmaceuticals

基　　金：湖北省卫生和计划生育委员会科研项目[WJ2015MB127]

摘　　要：目的探讨血液灌流联合纳洛酮对安眠药中毒患者抢救成功率及呼吸状况的影响。方法选取医院2014年8月至2017年8月收治的安眠药中毒患者116例,根据不同治疗方法分为对照组和研究组,各58例。两组患者均予以常规对症支持治疗,研究组患者予血液灌流联合纳洛酮治疗。结果治疗后,两组平均动脉压(MAP)、血氧分压(PaO2)均较治疗前明显增高,动脉血二氧化碳分压(PaCO2)、酸碱值(pH)均较治疗前明显降低(P<0.05),且研究组均明显优于对照组(P<0.05);研究组意识恢复时间、完全苏醒时间、住院时间、血浆药物浓度降至正常范围时间均明显短于对照组(P<0.05);研究组肺部感染(1.72%)、昏迷(3.45%)、呼吸困难(3.45%)、恶心呕吐(1.72%)发生率均明显低于对照组(12.07%,13.79%,13.79%,15.52%,P<0.05);研究组抢救成功率为98.28%,明显高于对照组的79.31%(χ^2=10.482,P=0.001<0.05)。结论血液灌流联合纳洛酮治疗安眠药中毒,可有效提高患者的抢救成功率,明显改善呼吸状况,缩短生命体征恢复时间,有效减少并发症,值得临床推广。Objective To investigate effect of blood perfusion combined with naloxone on rescue success rate and respiratory status of patients with hypnotic poisoning.Methods Totally 116 patients with hypnotic poisoning admitted to our hospital from August 2014 to August 2017 were selected and divided into the control group and the study group,58 cases in each group.The patients in the two groups were given routine symptomatic supportive treatment,on this basis,the patients in the study group received the blood perfusion combined with naloxone.Results After treatment,the mean arterial pressure(MAP),blood oxygen partial pressure(PaO2)in the two groups were significantly higher than those before treatment,while the arterial carbon dioxide partial pressure(PaCO2)and pH in the two groups were significantly lower than those before treatment,and those in the study group were significantly better than those in the control group(P<0.05).The consciousness recovery time,complete recovery time,length of hospital stay,plasma drug concentration fell within the normal range in the study group were shorter than those in the control group(P<0.05).The incidence rates of pulmonary infection,coma,dyspnea and nausea and vomiting in the study group were 1.72%,3.45%,3.45%and 1.72%,which were significantly lower than 12.07%,13.79%,13.79%and 15.52%in the control group(P<0.05).The rescue success rate of the study group was 98.28%,which was significantly higher than 79.31%of the control group(χ^2=10.482,P=0.001).Conclusion The blood perfusion combined with naloxone in the treatment of hypnotic poisoning can effectively improve the rescue success rate,significantly improve the respiratory status,shorten the recovery time of vital signs,and effectively reduce complications,which is worthy of clinical promotion.

关 键 词：血液灌流 纳洛酮 安眠药中毒 抢救成功率 呼吸状况 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]