二甲双胍联合多西他赛治疗乳腺癌并2型糖尿病临床研究  

Clinical Study on Metformin Combined with Docetaxel in the Treatment of Patients with Breast Cancer Complicated with Type 2 Diabetes Mellitus

作　　者：高伟聪[1] 李丽[1] 张中华 朱向辉[1] 刘素巧[1] GAO Weicong;LI Li;ZHANG Zhonghua;ZHU Xianghui;LIU Suqiao(Department of Clinical Laboratory,Shijiazhuang Second Hospital,Shijiazhuang,Hebei,China 052360)

机构地区：[1]河北省石家庄市第二医院检验科

出　　处：《中国药业》2019年第12期81-83,共3页China Pharmaceuticals

基　　金：2017年河北省石家庄市科学技术研究与发展指导计划项目[171461463]

摘　　要：目的探讨二甲双胍联合多西他赛治疗乳腺癌并2型糖尿病的临床效果及对患者血清相关因子的影响。方法选择医院2015年3月至2016年3月收治的乳腺癌并2型糖尿病患者76例,按治疗方法的不同分为对照组和试验组,各38例。两组患者均予多西他赛,试验组患者在此基础上予二甲双胍。结果与治疗前比较,两组患者治疗后血清糖化血红蛋白(HbA1C)、癌胚抗原(CEA)、血管内皮生长因子(VEGF)、视黄醇结合蛋白4(RBP4)水平和胱天蛋白酶-3(Caspase-3)表达水平显著降低,胱天蛋白酶-9(Caspase-9)表达水平显著升高(P <0. 05),且试验组显著优于对照组(P <0. 05);试验组临床受益率为94. 74%,显著高于对照组的78. 95%(P <0. 05);两组不良反应发生率无显著差异(P> 0. 05)。结论二甲双胍联合多西他赛治疗乳腺癌合并2型糖尿病可提高临床受益率,改善HbA1C,CEA,VEGF,RBP4,Caspase-3及Caspase-9水平,且不增加不良反应。Objective To investigate the clinical effect of metformin combined with docetaxel in the treatment of patients with breast cancer complicated with type 2 diabetes mellitus( T2 DM) and its effect on serum related factors. Methods Totally 76 patients with breast cancer complicated with T2 DM admitted to our hospital from March 2015 to March 2016 were selected and divided into the control group and the experimental group according to different treatment methods,38 cases in each group. The patients in the two groups were given docetaxel,on this basis,the patients in the experimental group were given metformin. Results Compared with before treatment,the levels of serum glycosylated hemoglobin( Hb A1 C),carcinoembryonic antigen( CEA),vascular endothelial growth factor( VEGF),retinol binding protein 4( RBP4) and Caspase-3 in the two groups were significantly lower after treatment,while the levels of Caspase-9 in the two groups were significantly higher after treatment,and those in the experimental group were significantly better than those in the control group( P < 0. 05). The clinical benefit rate of the experimental group was 94. 74%,which was significantly higher than 78. 95% of the control group( P < 0. 05). There was no significant difference in the incidence of adverse reactions between the two groups( P > 0. 05). Conclusion Metformin combined with docetaxel in the treatment of with breast cancer complicated with T2 DM can increase the clinical benefit rate,improve the levels of HbA1 C,CEA,VEGF,RBP4,Caspase-3 and Caspase-9 without increasing the adverse reactions.

关 键 词：二甲双胍 多西他赛 乳腺癌 2型糖尿病 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R977.15[医药卫生—药学]