不同方案治疗多囊卵巢综合征的疗效观察  

Therapeutic Effect of Different Schemes on the Treatment of Polycystic Ovary Syndrome

作　　者：谭秋慧[1] TAN Qiuhui(Gaozhou People’s Hospital,Gaozhou 525200,China)

机构地区：[1]高州市人民医院

出　　处：《现代医院》2019年第5期744-746,共3页Modern Hospitals

摘　　要：目的探讨不同治疗方案对多囊卵巢综合征的治疗效果。方法选择多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)患者60例作为研究对象,随机分为二甲双胍组和罗格列酮组,各30例。二甲双胍组给予环丙孕酮炔雌醇(达英-35)及二甲双胍治疗,罗格列酮组给予达英-35和罗格列酮治疗,比较两组的临床疗效及不良反应。结果二甲双胍组的体质量指数降低更明显(P<0.05),罗格列酮组的稳态模型IR指数(HOMA-IR)、黄体生成素(LH)、卵泡刺激素(FSH)、血清睾酮(T)降低更明显,排卵率更高(P<0.05)。两组的不良反应无明显差异(P>0.05)。结论达英-35联合罗格列酮能显著提高PCOS患者临床疗效,改善患者的LH、FSH、T、HOMA-IR及排卵率,而达英-35联合二甲双胍对于肥胖的PCOS疗效更好,应该给予患者个体化的治疗方案。Objective To explore the effects of different treatments for polycystic ovary syndrome.Methods Sixty patients of PCOS were randomly divided into Metformin group and Rosiglitazone group,with 30 cases in each group.Metformin group wastreated by diane-35 and metformin,while Rosiglitazone group was treated with diane-35 and rosiglitazone.The clinical effects and side effects were compared between two groups.Results After treatment,body mass index in the patients of Metformin group was significantly decreased compared with Rosiglitazone group(P<0.05).While homeostasis model assessment insulin resistance index,luteinizing hormone,follicule-stimulating hormone,testosterone in Rosiglitazone group were decreased significantly(P<0.05).And the ovulation rate was increased significantly(P<0.05).There were no statistically significant differences in the side effects between the two groups.Conclusion Diane-35 and rosiglitazone can significantly improve the clinical effect of patients with PCOS,and can improve LH,FSH,T,HOMA-IR,the ovulation rate.Diane-35 and metformin are good for fat patients with PCOS.Individualized treatment methods should be given to patients.

关 键 词：多囊卵巢综合征 达英-35 二甲双胍 罗格列酮 

分 类 号：R711.75[医药卫生—妇产科学]