miRNA调控支气管哮喘研究进展  

Research progress of microRNAs in regulating bronchial asthma

作　　者：李雪静[1] 张园园[1] 陈志敏[1] LI XueJing;ZHANG Yuanyuan;CHEN Zhimin(Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052,Zhejiang, China)

机构地区：[1]浙江大学医学院附属儿童医院呼吸科

出　　处：《临床儿科杂志》2019年第6期466-469,共4页Journal of Clinical Pediatrics

基　　金：国家自然科学基金项目(No.81870023)

摘　　要：支气管哮喘是一种异质性疾病,可存在气道炎症、可逆性气道梗阻、气道高反应性和气道重塑。微小RNA(miRNAs)是一类转录后水平基因调节的非编码小RNA,在哮喘的发生发展中起着重要的调控作用。文章综述miRNAs在哮喘气道炎症和气道重塑中的研究进展,以及miRNAs作为治疗哮喘新靶点的可能。Bronchial asthma is a heterogeneous disease and could have airway in flammation,reversible airway obstruction,airway hyperresponsiveness and airway remodeling.MicroRNAs(miRNAs)are a class of small non-coding RNAs involved in post-transcriptional gene repression and play a major regulating role in the development and progression of asthma.This review summarizes the current understanding of miRNAs in the regulation of airway in flammation and airway remodeling in asthma.Furthermore,miRNAs are also shown to be targets for asthma therapy in the future.

关 键 词：哮喘 微小RNA 炎症 气道重塑 治疗靶点 

分 类 号：R725.6[医药卫生—儿科]