降钙素在治疗骨质疏松伴腰椎管狭窄症中的应用价值  

Application value of calcitonin in the treatment of osteoporosis with lumbar spinal stenosis

作　　者：黎佩珍[1] 翁阳华[1] 伊莉[1] 张洪亮[1] 李忠辉[1] 杨宏栋[2] LI Pei-zhen;WENG Yang-hua;YI Li;ZHANG Hong-liang;LI Zhong-hui;YANG Hong-dong(Department of Rehabilitation,Dongguan Humen Hospital,Dongguan 523900,Guangdong,CHINA;Department of Orthopedics ,Dongguan Humen Hospital,Dongguan 523900,Guangdong,CHINA)

机构地区：[1]东莞市虎门医院康复科,广东东莞523900 [2]东莞市虎门医院骨科,广东东莞523900

出　　处：《海南医学》2019年第11期1378-1380,共3页Hainan Medical Journal

基　　金：2017年广东省东莞市社会科技发展(一般)项目(编号:201750715020219)

摘　　要：目的探讨降钙素治疗骨质疏松伴腰椎管狭窄症的临床疗效。方法选择2013年1月至2018年6月期间东莞市虎门医院收治的68例骨质疏松合并腰椎管狭窄症患者为研究对象,根据随机数表法分为观察组(n=34)和对照组(n=34),对照组患者予钙尔奇D+洛索洛芬钠治疗,观察组患者在此基础上联合鲑鱼降钙素治疗,疗程均为4周。比较两组患者的临床疗效,以及治疗后疼痛程度[视觉模拟评分法(VAS)]、腰椎功能[日本骨科协会评估治疗分数(JOA)]的变化。结果治疗后,观察组患者的治疗有效率为85.29%,明显高于对照组的61.76%,差异有统计学意义(P<0.05);治疗前,两组患者的VAS评分及腰椎JOA评分比较差异均无统计学意义(P>0.05);治疗后观察组患者的VAS评分为(3.44±1.31)分,明显低于对照组的(4.82±1.39)分,JOA评分为(19.72±5.14)分,明显高于对照组的(17.04±4.42)分,差异均有统计学意义(P<0.05)。结论降钙素治疗骨质疏松伴腰椎管狭窄症可以缓解患者的疼痛症状,改善腰椎功能,提高临床疗效。Objective To investigate the clinical effect of calcitonin in the treatment of osteoporosis with lumbar spinal stenosis. Methods Sixty-eight patients with osteoporosis complicated with lumbar spinal stenosis treated in Dongguan Humen Hospital from January 2013 to June 2018 were selected as the research objects. According to the random number table method, they were divided into observation group(n=34) and control group(n=34). The patients of control group were treated with Calcium D+Losoprofen Sodium, and those in the observation group were treated with salmon calcitonin on this basis of the treatment in the control group. The course of treatment was 4 weeks. The clinical efficacy, pain degree(Visual Analogue Scale [VAS]) and lumbar vertebral function(JOA) were compared between the two groups. Results After treatment, the effective rate of the observation group was 85.29%, which was significantly higher than 61.76% of the control group(P<0.05). Before treatment, there was no significant difference in VAS score and JOA score between the two groups(P>0.05). The VAS score of the observation group were 3.44±1.31, which were significantly lower than 4.82±1.39 of the control group. The JOA score were 19.72±5.14, which were significantly higher than 17.04±4.42 of the control group(P<0.05). Conclusion Calcitonin in the treatment of osteoporosis with lumbar spinal stenosis can relieve pain symptoms, improve lumbar function, and improve clinical efficacy.

关 键 词：骨质疏松 腰椎管狭窄 降钙素 腰椎功能 疗效 

分 类 号：R681[医药卫生—骨科学]