外泌体参与糖尿病心肌病发病的研究进展  

Advances in research on the involvement of exosomes in the pathogenesis of diabetic cardiomyopathy

作　　者：姚杰春 郭润民 梁伟钧 YAO Jie-chun;GUO Run-min;LIANG Wei-jun(Department of Cardiology,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,Guangdong,CHINA)

机构地区：[1]广东医科大学附属医院心血管内科

出　　处：《海南医学》2019年第11期1451-1454,共4页Hainan Medical Journal

基　　金：广东省科技计划项目(编号:20110316)

摘　　要：糖尿病心肌病(DbCM)是一种独立于冠状动脉疾病、瓣膜病、先天性心脏病、高血压心脏病以代谢障碍及心肌功能障碍为特征的心血管并发症,其临床表现为早期心脏舒张功能受损,晚期收缩功能受损,最终发展为心力衰竭。DbCM病理过程较为复杂,而外泌体中的某些生物成分可能在DbCM的病理过程中起重要作用。本研究主要从糖尿病心肌病的发病机制、外泌体在DbCM中的作用等方面综述外泌体与糖尿病心肌病的最新进展,有可能为DbCM的早期识别及治疗提供新的方向。Diabetic cardiomyopathy (DbCM) is a cardiovascular complication independent of coronary artery disease, valvular disease, congenital heart disease, and hypertensive heart disease, characterized by metabolic disorders and myocardial dysfunction. Its clinical manifestations are early impaired diastolic function, impaired late systolic function, and eventually heart failure. The pathological process of DbCM is complicated, and some biological components in exosomes may play an important role in the pathological process of DbCM. Therefore, this study reviews the recent advances in exocytosis and diabetic cardiomyopathy from the pathogenesis of diabetic cardiomyopathy and the role of exosomes in DbCM, which may provide a new direction for the early identification and treatment of DbCM.

关 键 词：糖尿病心肌病 冠状动脉疾病 发病机制 外泌体 治疗 

分 类 号：R587.2[医药卫生—内分泌]