复方α-酮酸联合血液净化治疗尿毒症的疗效及对患者QOL评分的影响  

Efficacy of compound α-ketoacid combined with blood purification in the treatment of uremia and its effect on QOL score

作　　者：朱兴华[1] 李颖玉[1] 陈璐[1] 丘宝珍 杜春荔[1] 张蔼玲[1] ZHU Xinghua;LI Yingyu;CHEN Lu;QIU Baozhen;DU Chunli;ZHANG Ailing(Blood Purification Center,the People's Hospital of Meizhou City in Guangdong Province,Meizhou 514031,China)

机构地区：[1]广东省梅州市人民医院血液净化中心

出　　处：《中国现代医生》2019年第13期26-29,34,共5页China Modern Doctor

摘　　要：目的探讨复方α-酮酸联合血液净化治疗尿毒症的效果及对患者QOL评分的影响。方法选取2016年6月~2017年6月在我院血液净化中心治疗的尿毒症患者78例,随机分为两组,对照组应用血液净化治疗,观察组应用复方α-酮酸联合血液净化治疗。比较两组患者治疗效果、β2-MG(血清β2-微球蛋白)、PTH(血清甲状旁腺素)、Cr(肌酐)、BUN(血尿素氮)值的变化、QOL(生命质量量表)评分、生活质量。结果对照组有效率为87.1%,观察组有效率为97.4%,观察组疗效优于对照组,差异有统计学意义(P<0.05);观察组治疗前β2-MG、PTH、Cr、BUN水平与对照组治疗前相比,无明显差异(P>0.05),观察组治疗后β2-MG、PTH、Cr、BUN值低于对照组,差异有统计学意义(P<0.05),两组治疗前β2-MG、PTH、Cr、BUN水平高于治疗后,差异有统计学意义(P<0.05);观察组治疗前QOL评分与对照组相比,无明显差异(P>0.05),观察组治疗后6个月、10个月QOL评分高于对照组,差异有统计学意义(P<0.05);观察组治疗前生活质量与对照组治疗前相比,无明显差异(P>0.05),观察组治疗后生活质量高于对照组,差异有统计学意义(P<0.05),两组治疗后生活质量高于治疗前,差异有统计学意义(P<0.05)。结论在尿毒症患者的治疗过程中,复方α-酮酸联合血液净化治疗效果较好,提高患者的生活质量,值得在临床上应用推广。Objective To investigate the effect of compoundα-ketoacid combined with blood purification on uremia and its influence on QOL score.Methods A total of 78 patients with uremia who were treated in our Blood Purification Center from June 2016 to June 2017 were randomly divided into two groups.The control group was treated with blood purification.The observation group was treated with compoundα-ketoacid combined with blood purification.The therapeutic effects,the changes ofβ2-MG(serumβ2-microglobulin),PTH(serum parathyroid hormone),Cr(creatinine)and BUN(blood urea nitrogen),and QOL(Life Quality Scale)score,and quality of life were compared between the two groups.Results The effective rate of the control group was 87.1%,which was better than that of the control group(97.4%),and the difference was statistically significant(P<0.05).There was no significant difference in the levels ofβ2-MG,PTH,Cr and BUN between the observation group and the control group before treatment(P>0.05).Theβ2-MG,PTH,Cr(creatinine)and BUN values in the observation group were lower than those in the control group after treatment(P<0.05).The levels ofβ2-MG,PTH,Cr and BUN between the two groups before treatment were higher than those after treatment(P<0.05).There was no significant difference in QOL score between the observation group and the control group before treatment(P>0.05).The QOL score of the observation group was higher than that of the control group after 6 and 10 months after treatment,and the difference was significant(P<0.05).There was no significant difference in the quality of life between the observation group and the control group before treatment(P>0.05).The quality of life of the observation group was higher than that of the control group after treatment,and the difference was statistically significant(P<0.05).The quality of life between the two groups after treatment was higher than that before treatment,and the difference was statistically significant(P<0.05).Conclusion In the treatment of uremia patients,compoundα-ket

关 键 词：复方Α-酮酸 血液净化 尿毒症 QOL评分 

分 类 号：R692.5[医药卫生—泌尿科学]