地榆化学成分的研究  

Chemical constituents from Sanguisorba officinalis

作　　者：王丽娜[1] 冯丹[1] 胡瀚文 吴雪彤 郭大乐[1] 邓赟[1] WANG Li-na;FENG Dan;HU Han-wen;WU Xue-tong;GUO Da-le;DENG Yun(Breeding Base of State Key Laboratory of Scientific Research and Exploitation of Traditional Chinese Medicine Resources,the Ministry of Education Key Laboratoryof Standardization of Chinese Herbal Medicine,Pharmacy College,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室-省部共建国家重点实验室培育基地

出　　处：《中成药》2019年第6期1298-1303,共6页Chinese Traditional Patent Medicine

基　　金：国家科技部新药创制重大专项(2014ZX09201021-008);中药药效物质基础研究与创新中药发现四川省青年科技创新研究团队(2016TD0006);四川省科技厅支撑计划项目中药种质资源库建设关键技术研究及示范(2014SZ0156);基于Mucor sp.cx-007对丹参酮ⅡA羟基化修饰相关研究(ZRQN1766)

摘　　要：目的研究地榆Sanguisorba officinalis L.的化学成分。方法地榆70%乙醇提取物20%乙醇部位采用大孔树脂、Toyopearl HW-40、反相硅胶进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到13个化合物,分别鉴定为4-allyl-2-hydroxyphenyl-1-O-apiosyl-(1-6)-β-D-glucopyranosid(1)、2,3-digalloyl-O-methylglucose(2)、methyl benzoate-4-β-D-glucopyranoside(3)、1-popanone,1-[4-[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]oxy]-2-hydroxyphenyl]-3-(4-hydroxyphenyl)(4)、1,2,3,4-tetrahydro-6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methyl-2-naphthalenemethanol(5)、2R,3S,2″R,3,8″-binaringenin-7″-O-β-glucoside(6)、glucosyringic acid(7)、rosarin(8)、leeaoside(9)、(+)-isolariciresinol-9-O-β-D-glucopyranoside(10)、niga-ichigoside F_l(11)、ziyu-glycosideⅠ(12)、3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyolean-12-en-28-oic acid 8-β-D-glucopyranoside(13)。结论化合物1~10为首次从该植物中分离得到。AIM To study the chemical constituents from Sanguisorba officinalis L.. METHODS The 20% ethanol fraction of 70% ethanol extract from Sanguisorba officinalis L. was isolated and purified by macroporous resin,Toyopearl HW-40 and reversed phase silica,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Thirteen compounds were isolated and identified as 4-allyl-2-hydroxyphenyl-1-O-apiosyl-(1-6)-β-D-glucopyranosid(1), 2,3-digalloyl-O-methylglucose(2), methyl benzoate-4-β-D-glucopyranoside(3), 1-popanone,1-[4-[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]oxy]-2-hydroxyphenyl]-3-(4-hydroxyphenyl)(4), 1,2,3,4-tetrahydro-6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methyl-2-naphthalenemethanol(5), 2R,3S,2″R,3,8″-binaringenin-7″-O-β-glucoside(6), glucosyringic acid(7), rosarin(8), leeaoside(9),(+)-isolariciresinol-9-O-β-D-glucopyranoside(10), niga-ichigoside F_l(11), ziyu-glycoside Ⅰ(12), 3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyolean-12-en-28-oic acid 8-β-D-glucopyranoside(13).CONCLUSION Compounds 1-10 are isolated from this plant for the first time.

关 键 词：地榆 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]