正交试验法研究湿热消颗粒的成型工艺  

Studying on the Molding Technology of ShiReXiao Granules by Orthogonal Experiment

作　　者：梁国成[1,2] 陈舒茵 黄小鸥[1] 方建康[1] 冯文勇[1] 覃翔 

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011 [2]广西大学,广西南宁530004

出　　处：《大众科技》2019年第4期70-71,111,共3页Popular Science & Technology

基　　金：广西高校中青年教师基础能力提升项目;2017年广西教育厅青年教师基础能力提升项目(2017KY0290)

摘　　要：目的:优选湿热消颗粒的制备工艺。方法:以软材综合评分和颗粒成型率百分比为指标,考察浸膏用量、蔗糖用量、糊精用量以及95%酒精用量四个关键因素对颗粒制备工艺的影响。结果:优选的最佳工艺为1倍量的浸膏(以0.1%酒精调和)、1.5倍量的蔗糖和2.5倍量的糊精制软材,再制粒、干燥和整粒;验证试验结果表明,软材平均评分为9.5分,RSD=1.94%,平均成型率为96.72%,RSD=2.57%。结论:优选的该制剂成型工艺可行、工艺稳定,可用于湿热消颗粒的扩大化实际生产。Objective: To select the optimum preparation technology of ShiReXiao Granules. Methods: To investigate the effects of four key factors, the amount of extract, the amount of sucrose, the amount of dextrin and the amount of 95% alcohol, which influence on the preparation process of the granules using the comprehensive score of soft materials and the percentage of particle forming rate for indexes. Results: The optimum process is 1 times the amount of extract (mixed with 0.1% alcohol), 1.5 times the amount ofsucrose and 2.5 times the amount of dextrin to produce soft materials, and then granulating, drying and granulating. The verification test results showed that the average score of soft materials was 9.5, RSD=1.94%, the average molding rate was 96.72%, RSD=2.57%. Conclusion: The optimum formulation is feasible and stable, and can be used in the practical production of the ShiReXiao Granules.

关 键 词：湿热消颗粒 正交试验 制备工艺 

分 类 号：TQ46[化学工程—制药化工]