正交试验法优化柴胡利胆颗粒的水提工艺研究  

Optimization of Water Extraction Process of Chaihu Lidan Granules by Orthogonal Experiment

作　　者：陈舒茵[1] 梁国成[1,2] 唐友明 梁春才[1] 黄小鸥[1] 冯文勇[1] 高春萍 黄敏[3] 

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011 [2]广西大学,广西南宁530004 [3]广西中医药大学第一附属医院,广西南宁530023

出　　处：《大众科技》2019年第5期55-57,共3页Popular Science & Technology

基　　金：广西高校中青年教师基础能力提升项目;2016年教育厅青年教师基础能力提升项目(KY2016YB207)

摘　　要：为优化柴胡利胆颗粒的水提工艺,以干膏得量和总黄酮含量为指标,重点考察药材浸泡时间(h)、提取溶剂用量(倍)、提取时间(h)和提取次数(次)4个关键因素对该制剂在传统工艺条件下对水提工艺的影响。结果表明,优选的最佳水提取工艺为:加12倍量的水浸泡0.8h、提取2次、每次提取时间为2h;按处方10倍放大实验,在最佳水提工艺条件下,水提干膏平均得量为332.8566g(RSD=2.66%),平均总黄酮含量为1.25mg/g,(RSD=1.21%)。To optimize the water extraction process of Chaihu Lidan Granules, taking dry extract yield and total flavonoid content as indexes, the effects of four key factors on the water extraction process of the preparation under traditional conditions were investigated, including soaking time (h), solvent dosage (times), extraction time (h) and extraction times (times). The results showed that the optimum water extraction process was as follows: adding 12 times of water, soaking for 0.8 hours, extracting twice and extracting for 2 hours each time;according to the 10 times enlargement experiment, under the optimum water extraction conditions, the average yield of water extract was 332.8566 g (RSD=2.66%), and the average total flavonoid content was 1.25 mg/g (RSD=1.21%).

关 键 词：正交试验 柴胡利胆颗粒 水提工艺 

分 类 号：R284[医药卫生—中药学]