肠易激综合征中肠道菌群与活性氧的相关性研究  

Relationship between gut flora and reactive oxygen species in irritable bowel syndrome

作　　者：柯少雄 杨长青[1] 魏子白[1] KE Shaoxiong;YANG Changqing;WEI Zibai(Department of Gastroenterology,Peace Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院消化内科

出　　处：《胃肠病学和肝病学杂志》2019年第6期701-704,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(81600422)

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是最常见的功能性胃肠道疾病之一,其病因和发病机制尚不完全清楚,但肠道菌群已被认为是IBS发生和发展的重要因素之一,最新研究发现,肠道菌群介导IBS内脏疼痛的发生,可能与肠上皮细胞中活性氧(reactive oxygen species,ROS)的产生密切相关。本文就近年来IBS中肠道菌群与ROS的相关性研究作一概述。Irritable bowel syndrome(IBS) is one of the most common functional gastrointestinal diseases. The etiology and pathogenesis of IBS are not completely clear, but the gut flora has been considered as one of the important factors in the occurrence and development of IBS. Recent studies have found that gut flora mediates the occurrence of visceral pain in IBS, which may be closely related to the production of reactive oxygen species(ROS) in intestinal epithelial cells. This paper reviewed the recent studies on the relationship between gut flora and ROS in IBS.

关 键 词：肠易激综合征 肠道菌群 活性氧 内脏疼痛 

分 类 号：R37[医药卫生—病原生物学]