高尿酸血症与小于胎龄儿发生的相关性  

ASSOCIATION BETWEEN HYPERURICEMIA AND SMALL-FOR-GESTATIONAL-AGE INFANTS

作　　者：梁楠[1] 孙文艳 李鑫德[3] 潘明子 贾兆通[1] LIANG Nan;SUN Wenyan;LI Xinde;PAN Mingzi;JIA Zhaotong(Department of Endocrine and Metabolic Diseases, The Affiliated Hospital of Qingdao University, Qingdao 266003, China)

机构地区：[1]青岛大学附属医院内分泌与代谢性疾病科,山东青岛266003 [2]青岛大学代谢病研究院 [3]青岛大学附属医院山东省代谢病重点实验室

出　　处：《青岛大学学报（医学版）》2019年第4期419-422,共4页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金资助项目(81801434,81602258)

摘　　要：目的探讨高尿酸血症是否是小于胎龄儿发生的危险因素。方法选取2014年1月—2019年3月在我院产科住院生产的产妇8046例,根据是否分娩了小于胎龄儿分为小于胎龄儿组(639例)和非小于胎龄儿组(7407例),采集产妇和新生儿的相关信息,进行Logistic回归分析,探讨小于胎龄儿发生的危险因素。结果并发妊娠期高血压疾病(OR=4.099,P<0.001)、羊水过少(OR=2.818,P<0.001)、并发高尿酸血症(OR=1.970,P<0.001)、早产(OR=1.273,P<0.05)是分娩小于胎龄儿的危险因素;妊娠期体质量增加、并发妊娠期糖尿病或糖尿病合并妊娠、分娩次数多的孕妇,小于胎龄儿的发生风险较低。结论高尿酸血症可能是孕妇分娩小于胎龄儿的独立危险因素。Objective To investigate whether hyperuricemia is a risk factor for small-for-gestational-age(SGA) infants. Methods A total of 8 046 parturients in our hospital from January 2014 to March 2019 were enrolled, and the subjects were divi-ded into SGA group(n=639) and non-SGA group(n=7 407) according to whether an SGA infant was delivered. Relevant information of parturients and infants were collected to perform a logistic regression analysis and to investigate the risk factors for SGA infants. Results Gestational hypertension(OR=4.099,P<0.001), oligohydramnios(OR=2.818,P<0.001), hyperuricemia(OR=1.970,P<0.001), and premature delivery(OR=1.273,P<0.05) were found to be the risk factors for SGA, and pregnancy with an increased body mass index, gestational diabetes or pregnancy with pre-existing diabetes, and multiple deliveries were found to be associated with lower risk of SGA. Conclusion Hyperuricemia may be an independent risk factor for SGA infants.

关 键 词：婴儿 小于胎龄 危险因素 高尿酸血症 

分 类 号：R723.19[医药卫生—儿科] R589.9[医药卫生—临床医学]