老年社区获得性肺炎不同人群血清PCT水平表达的差异性研究  

Analysis on the Difference of Serum PCT Expression in Elderly Patients with Community-Acquired Pneumonia

作　　者：李志强[1] 吴正霞[1] 张和平[1] 陈凯[1] 张颖 LI Zhi-qiang;WU Zheng-xia;ZHANG He-ping;CHEN Kai;ZHANG Ying(Department of Respiratory Medicine,Baoji Central Hospital,ShaanxiBaoji 721008,China;Department of Respiratory Medicine,Yulin Hospital of Traditional Chinese Medicine,Shaanxi Yulin 719000,China)

机构地区：[1]宝鸡市中心医院呼吸内科,陕西宝鸡721008 [2]榆林市中医医院呼吸内科,陕西榆林719000

出　　处：《现代检验医学杂志》2019年第3期74-76,81,共4页Journal of Modern Laboratory Medicine

基　　金：陕西省卫生健康科研基金(编号:2018SF-218)

摘　　要：目的分析老年社区获得性肺炎(community acquired pneumonia,CAP)不同人群中血清降钙素原(procalcitonin,PCT)表达水平的差异。方法回顾性分析2017年11月~2018年11月间在宝鸡市中心医院呼吸内科收治的205例老年CAP患者,依照患者基础疾患分为肺癌组(n=39)、慢性呼吸系统疾病组(n=58)、糖尿病组(n=42)及无基础疾患组(n=66),所有患者采静脉血测定PCT和CRP并分析其表达水平是否存在差异及其意义。结果糖尿病组、肺癌组、无基础疾患组和慢性呼吸系统疾病组PCT表达水平分别为0.61±0.49,0.50±0.71,0.35±1.07和0.27±0.63μg/L,四组比较差异有统计学意义(F=8.274,P<0.05),阳性率(78.6%,71.8%,45.5%和48.3%)比较,差异有统计学意义(χ^2=10.634,P<0.05);CRP表达水平分别为23.09±16.75,19.89±17.31,36.43±26.12和24.59±15.86 mg/L,四组比较,差异无统计学意义(F=4.487,P>0.05),阳性率(69.0%,59.0%,75.8%和72.4%)比较,差异无统计学意义(χ^2=3.489,P>0.05)。结论在不同老年CAP人群中糖尿病患者PCT表达水平及阳性率最高,更具有临床指导价值。Objective To study the expression levels of serum procalcitonin(PCT) in elderly patients with community acquired pneumonia.Methods According to whether had underlying diseases,205 elderly patients with CAP admitted to the Department of Respiratory Medicine of Baoji Central Hospital were divided into lung cancer group(n=39),chronic respiratory disease group(n=58),diabetes group(n=42) and non-underlying disease group(n=66).PCT and CRP were measured by venous blood sampling in all patients and their expression levels were analyzed.Results The difference in PCT expression level between diabetes group,lung cancer group,non-underlying disease group and chronic respiratory disease group(0.61±0.49,0.50±0.71,0.35±1.07 and 0.27±0.63 μg/L) were statistically significant(F=8.274,P<0.05),and the positive rates(78.6%,71.8%,45.5% and 48.3%) were statistically significant(χ^2=10.634,P<0.05),too.There was no significant difference(F=4.487,P>0.05) in CRP expression level between diabetics group,lung cancer group,non-underlying disease group and chronic respiratory disease group(23.09±16.75,19.89±17.31,36.43±26.12 and 24.59±15.86 mg/L),and the positive rates(69.0%,59.0%,75.8% and 72.4%) were the same(χ^2=3.489,P>0.05).Conclusion The PCT expression level of diabetic patients was the highest in different elderly CAP population,which has more clinical guiding value.

关 键 词：社区获得性肺炎 降钙素原 老年 差异性 

分 类 号：R563.1[医药卫生—呼吸系统] R446.11[医药卫生—内科学]