两种剂量右美托咪定对老年患者全麻气管插管应激反应、血流动力学及不良反应的影响  

Effects of Two Different Doses of Dexmedetomidine on Stress Response, Hemodynamics and Adverse Reactions in Elderly Patients with Tracheal Intubation

作　　者：李小静[1] 陈文佳 朱雅斌[1] 钱涛 孙灿林[1] LI Xiao-jing;CHEN Wen-jia;ZHU Ya-bin;QIAN Tao;SUN Can-lin(Taizhou People's Hospital, Taizhou Jiangsu 225300, China)

机构地区：[1]泰州市人民医院麻醉科

出　　处：《泰州职业技术学院学报》2019年第2期55-57,共3页Journal of Taizhou Polytechnic College

摘　　要：目的探讨两种剂量右美托咪定对老年气管插管患者应激反应、血流动力学及不良反应的影响。方法将行气管插管的60例老年患者以随机数字表法分为对照组30例,观察组30例。观察组在麻醉诱导前泵注右美托咪定0.5μg/kg,对照组泵注0.8μg/kg,分别对两组不同时间段应激反应、血流动力学进行观察,同时记录不良反应发生情况。结果观察组T1时MAP、HR、SpO2及RR与对照组比较无明显差异(P>0.05),两组T2-T4时各指标较T1时有明显变化(P<0.05),组间比较差异无统计学意义(P>0.05);观察组不良反应发生率为10.00%,比对照组33.33%明显更低(P<0.05)。结论0.5μg/kg右美托咪定和0.8μg/kg右美托咪定均能够有效抑制老年患者气管插管时应激反应,维持血流动力学稳定,但0.5μg/kg右美托咪定不良反应发生率更少,安全性更高,值得推广。Objective To investigate the effects of two different doses of dexmedetomidine on stress response, hemodynamics and adverse reactions in elderly patients with tracheal intubation. Methods 60 elderly patients who underwent tracheal intubation from February 2016 to November 2018 were randomly divided into the control group(n=30) and the observation group(n=30), patients in the observation group received dexmedetomidine0.5μg/kg within 10 min before anesthesia induction, and patients in the control group received 0.8μg/kg. Observed the stress response and hemodynamics of the two groups at three different time points, and recorded the occurrence of adverse reactions. Results There was no significant difference in MAP, HR, SpO2 and RR between the observation group and the control group at T1(P>0.05).There were significant changes in the indexes between the two groups at T2~T4 compared with T1(P < 0.05).There was no significant difference between groups(P > 0.05).The incidence of adverse reactions in the observation group was 10.00%,compared with the control group(33.33%), which was significantly lower(P < 0.05). Conclusion 0.5μg/kg dexmedetomidine and0.8μg/kg dexmedetomidine can effectively inhibit the stress response and maintain hemodynamic stability during tracheal intubation in elderly patients. When use dexamethasone with the dose of 0.5μg/kg,the incidence of adverse reactions is lower than the dose of 0.8 ug/kg, which is safer and worth promoting.

关 键 词：右美托咪定 气管插管 应激反应 血流动力学 不良反应 

分 类 号：R614[医药卫生—麻醉学]