三苯基膦催化下联烯丁酸酯与橙酮的陆氏[3+2]环化反应研究:制备螺[1-苯并呋喃-3-酮-2,5’-环戊烯]类化合物  

Triphenylphosphine Catalyzed Lu’s [3+2] Annulation of Aurones and Alkenoates: Constructing of Spiro[1-benzofuran-3-one-2,5’-cyclopentene] Polycyclic Compounds

作　　者：苏瀛鹏[1] 冯亚威 曹林丹 薛文轩 石娅 常兵兵 黄丹凤[1] 王克虎[1] 胡雨来[1] Su Yingpeng;Feng Yawei;Cao Lindan;Xue Wenxuan;Shi Ya;Chang Bingbing;Huang Danfeng;Wang Ke-Hu;Hu Yulai(College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070)

机构地区：[1]西北师范大学化学化工学院

出　　处：《有机化学》2019年第5期1333-1343,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21502154,21362033);甘肃省科技计划(No.17JR5RA073)资助项目~~

摘　　要：在PPh3催化下,橙酮和联烯酸酯可通过陆氏[3+2]环化反应成功构建含有螺[1-苯并呋喃-3-酮-2,5'-环戊烯]的多环结构单元.该反应条件温和,操作简单,并且底物适用性好,产率高.该方法学的研究为applanatumin A等天然产物的合成奠定了基础.The PPh3 catalyzed Lu's[3+2] annulation of aurones with alkenoates has been developed to form spiro-[1-ben-zofuran-3-one-2,5'-cyclopentene] polycyclic moiety. The usefulness of this strategy has been demonstrated by the use of a wide variety of substrates to give desired polycyclic compounds in high yield under mild and simple reaction condition. This methodology research offered a fine entry for synthesis of natural product applanatumin A and its analogues.

关 键 词：橙酮 联烯酸酯 三苯基膦 陆氏[3+2]环化反应 

分 类 号：O621.251[理学—有机化学]