锌-脯氨酸复合物催化的水相Knoevenagel缩合  

Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water

作　　者：颜世强[1,2] 郭伟 王文笙 张伟 Yan Shiqiang;Guo Wei;Wang Wensheng;Zhang Wei(School of Pharmacy, Fudan University, Shanghai 201203;Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300)

机构地区：[1]复旦大学药学院,上海201203 [2]山东达因海洋生物制药股份有限公司,威海264300

出　　处：《有机化学》2019年第5期1469-1474,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.81573340);山东省自主创新及成果转化专项(No.2015ZDXX0302A02)资助项目~~

摘　　要：报道了锌-脯氨酸复合物催化下的水相Knoevenagel缩合反应.17种芳香醛以及2种脂肪环酮与丙二腈在80℃下反应5~10min,能够以84%~99%的收率得到相应的Knoevenagel缩合产物.催化剂回收重复使用10次,其催化活性不受影响.Zinc-proline complex catalyzed Knoevenagel condensation in water was reported. Seventeen aldehydes and two ketones were investigated, which coupled with malononitrile smoothly affording desired Knoevenagel condensation products in 5~10 min at 80℃ in the yields of 84%~99%. The catalyst can be recovered and reused for ten cycles without loss of activity.

关 键 词：KNOEVENAGEL缩合 水相反应 锌-脯氨酸复合物 环境友好 

分 类 号：O621.251[理学—有机化学]