Plasma spray of biofunctional(Mg, Sr)-substituted hydroxyapatite coatings for titanium alloy implants  

作　　者：Lei Cao Ihsan Ullah Na Li Shiyu Niu Rujie Sun Dandan Xia Rui Yang Xing Zhang 

机构地区：[1]Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China [2]University of the Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China [3]School of Materials Science and Engineering, University of Science and Technology of China. Hefei 239056, China [4]Shenyang Pharmaceutical University, Shenyang 110016, China [5]University of Utah, Salt Lake City, UT 84112, USA

出　　处：《Journal of Materials Science & Technology》2019年第5期719-726,共8页材料科学技术（英文版）

基　　金：supported by the National Key Research and Development Program of China from Ministry of Science and Technology (No. 2016YFC1100502);the College Students’ Innovative Program of Liaoning Province (No. 201310163023);Key Research Program of Frontier Sciences (No. QYZDY-SSW-JSC027);the Hundred-Talent Program from Chinese Academy of Sciences (CAS);the Innovation Research Program from Institute of Metal Research, CAS (No. 2015-ZD01)

摘　　要：Plasma-sprayed hydroxyapatite (HA) coatings have been widely utilized in load-bearing titanium alloy implants. In this study, Mg, Sr co-substituted HA ((Mg,Sr)-HA) nano-scale powders have been synthesized, which are further used to prepare (Mg,Sr)-HA coatings on Ti-6A1-4V alloys in order to improve the biological functions. The average size of (Mg,Sr)-HA nano particles is ~75nm. The average bonding strength for (Mg,Sr)-HA coating and samples after heat treatment at 500℃ or 600℃ for 3h are 26.17±2.11 MPa, 36.07±4.48 MPa and 37.07 ±2.95 MPa, respectively. There is a significantly increase of bonding strength likely due to low residual stress after heated treatment.MC3T3-E1 cells show a high proliferation rate when cultured with (Mg,Sr)-HA coating extract compared to the normal culture medium, which also exhibit large extension and depositi on of extracellular matrices when adhered on the coating surfaces. Thus, these (Mg,Sr)-HA coatings show high bonding strength and improved biological functions, which offer promising future applications in the fields of orthopedics and dentistry.Plasma-sprayed hydroxyapatite(HA) coatings have been widely utilized in load-bearing titanium alloy implants. In this study, Mg, Sr co-substituted HA((Mg, Sr)-HA) nano-scale powders have been synthesized, which are further used to prepare(Mg, Sr)-HA coatings on Ti-6 Al-4 V alloys in order to improve the biological functions. The average size of(Mg, Sr)-HA nano particles is ～75 nm. The average bonding strength for(Mg, Sr)-HA coating and samples after heat treatment at 500°C or 600°C for 3 h are26.17 ± 2.11 MPa, 36.07 ± 4.48 MPa and 37.07 ± 2.95 MPa, respectively. There is a significantly increase of bonding strength likely due to low residual stress after heated treatment. MC3 T3-E1 cells show a high proliferation rate when cultured with(Mg, Sr)-HA coating extract compared to the normal culture medium, which also exhibit large extension and deposition of extracellular matrices when adhered on the coating surfaces. Thus, these(Mg, Sr)-HA coatings show high bonding strength and improved biological functions, which offer promising future applications in the fields of orthopedics and dentistry.

关 键 词：Plasma spray HYDROXYAPATITE Titanium alloys Biological functions BON ding strength 

分 类 号：TG[金属学及工艺]