甘草总黄酮双层缓释口腔贴膜的制备  

Preparation of Glycyrrhizic Flavone Bilayer Sustained-Release Oral Patch

作　　者：林晓春[1] 翁立冬[2] 张志勤 李旭桂[1] 郑锦坤[1] 李庆德[1] LIN Xiaochun;WENG Lidong;ZHANG Zhiqin;LI xugui;ZHENG Jinkun;LI Qingde(Yue Bei People's Hospital,Shaoguan,Guangdong 512025,China;School of Traditional Chinese Medicine,Southern Medical University,Guangzhou,Guangdong 510515,China)

机构地区：[1]粤北人民医院,广东韶关512026 [2]南方医科大学中医药学院,广东广州510515

出　　处：《今日药学》2019年第4期228-230,共3页Pharmacy Today

基　　金：广东省中医药局面上科研项目(20191325);广东省医院药学研究基金(2018A25);韶关市卫生计生科研项目(Y18082);广东省高校大学生创新创业训练计划项目(201812121158)

摘　　要：目的制备甘草总黄酮双层缓释口腔贴膜,并对其生物性能进行评价。方法以甘草总黄酮为主药,乙基纤维素(EC)作为空白隔离层,交联羧甲基纤维素钠(CCMC-Na)、海藻酸钠(ALG)、聚乙烯醇(PVA)为载药层膜材料,甘油作为保湿剂,吐温-80作为助溶剂,并采用L_9(3~4)正交试验设计优化载药膜材料配比,以外观性状、体外黏附力、成膜性和溶解性作为贴膜生物性能评价指标,确定载药膜材的最优配比。结果 EC为空白隔离层,载药层中CCMA-Na∶ALG∶PVA=2∶2∶1比例时,制成的载药膜生物性能最佳。结论甘草总黄酮-EC-CCMA-Na-ALG-PVA双层缓释口腔贴膜可作为新型口腔贴膜制剂。OBJECTIVE To study the preparation technology of glycyrrhizic flavone double-layer sustained-release oral patch and evaluate its performance. METHODS With glycyrrhizic flavone as the main drug,sodium carboxymethyl cellulose,sodium alginate and polyvinyl alcohol as drug-carrying membrane materials,ethyl cellulose as blank isolation layer,glycerol as moisturizing agent and Tween-80 as cosolvent,glycyrrhizic flavone bilayer sustained-release oral adhesive film was prepared.The proportion of drug-carrying membrane materials was optimized by L9( 3^4) orthogonal test design,and its appearance and mucosity were observed.Adhesion force,film forming ability and dissolution time were used as evaluation indexes to determine the optimum proportion of drug-loaded films. RESULTS The optimum ratio of cross-linked sodium carboxymethyl cellulose,sodium alginate and polyvinyl alcohol was 2 ∶ 2 ∶ 1. CONCLUSION Glycyrrhizic flavone-cross-linked sodium carboxymethyl cellulose-sodium alginate-polyvinyl alcohol bilayer sustained-release oral patch can be used as a new oral patch preparation.

关 键 词：甘草总黄酮 口腔贴膜 缓释 复发性口腔溃疡 制备工艺 

分 类 号：R460.6[医药卫生—临床医学]