阿胶肽-铁螯合物对缺铁性贫血小鼠的初步药效学研究  

The effect of ferrous-chelating colla corii asini hydrolysate on Iron-Deficiency Anemia in mice

作　　者：李敏 梁大连 邵珠德 王少平 李亚男 马青琳 王芳 LI Min;LIANG Da-lian;SHAO Zhu-de;WANG Shao-ping;LI Ya-nan;MA Qing-lin;WANG Fang(Shandong Academy of Pharmaceutical Sciences,Ji'nan Shandong,250101,China;Affiliated Hospital of Qingdao University,Qingdao Shandong,266071,China;Binzhou Medical Unversity,Yantai Shandong,264003,China;Shandong University of Traditional Chinese Medicine,Ji'nan Shandong 250355,China)

机构地区：[1]山东省药学科学院,山东济南250101 [2]青岛大学附属医院,山东青岛266071 [3]滨州医学院药学院,山东烟台264003 [4]山东中医药大学,山东济南250355

出　　处：《时珍国医国药》2019年第4期852-854,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家重大新药创制项目(2017ZX09301003);山东省重点研发计划(2016GSF202006)

摘　　要：目的以阿胶为原料,经蛋白酶酶解和氯化亚铁(FeCl_2·4H_2O)处理,对阿胶肽-铁螯合物(Fe(Ⅱ)-HCCA)的补血作用进行初步药效学研究。方法采用饲以低铁饲料造成的缺铁性贫血(IDA)小鼠模型,通过检测其血液指标,考察Fe(Ⅱ)-HCCA的补血效果。结果 Fe(Ⅱ)-HCCA能有效地恢复IDA小鼠血液学指标,达到正常水平,可显著增加HGB、HCT、MCV、MCH、CHCM和MCHC的值(P<0.01),降低HDW、RDW值(P<0.01),提示Fe(Ⅱ)-HCCA是IDA小鼠补铁的有效来源。结论阿胶肽-铁螯合液对缺铁性贫血的症状具有改善作用。Objective The preliminary pharmacodynamics of the Fe(Ⅱ)-hydrolysate of colla corii asini were studied by protease digestion and ferrous chloride(FeCl2·4 H2O) treatment.Methods The therapeutic effect of Fe(Ⅱ)-HCCA on blood rehydration was investigated by using a model of mice with iron deficiency anemia(IDA)caused by low iron diet.Results The results showed that Fe(Ⅱ)-HCCA had effective restorative action returning hematological parameters in IDA mices to normal level.The peptide-iron chelate can significantly increase the values of HGB, HCT, MCV, MCH,CHCM and MCHC in blood of mice with iron deficiency anemia(P<0.01),and decrease HDW,RDWvalue(P<0.01).The findings suggest that Fe(Ⅱ)-HCCA is an effective source of iron supplement for IDA mice.Conclusion Fe(Ⅱ)-HCCA can improve the symptoms of iron deficiency anemia.

关 键 词：阿胶肽-铁螯合物 缺铁性贫血 血液参数 

分 类 号：R285.5[医药卫生—中药学]