超滤-纳滤技术纯化、浓缩古汉养生精提取液的工艺研究  

Study on the Purification and Concentration Process for Water Extract of Guhan Yangshengjing with Ultrafiltration-Nanofiltration Technology

作　　者：张可人[1] 钟源 赵梦姣 谢康 阳佑华 邹龙[1] ZHANG Ke-ren;ZHONG Yuan;ZHAO Meng-jiao;XIE Kang;YANG You-hua;ZOU Long(Hunan University of Chinese Medicine,Changsha,Hunan,410208,China;Hengyang TCM Co.,Ltd.of Tus-Guhan Group Corporation,Hengyang,Hunan,421003,China;Engineering & Technology Research Center of Hunan TCM Liquid Preparation,Hengyang,Hunan,421003,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]启迪古汉集团衡阳中药有限公司,湖南衡阳421003 [3]湖南省中药液体制剂工程技术研究中心,湖南衡阳421003

出　　处：《时珍国医国药》2019年第4期874-876,共3页Lishizhen Medicine and Materia Medica Research

基　　金：湖南省科技厅县域经济发展技术创新引导专项项目(2015SK2094)

摘　　要：目的运用超滤-纳滤联用技术提高古汉养生精口服液的品质,降低生产成本,减少污染。方法以淫羊藿苷截留率为指标,考察不同截留分子量、压力、温度3个因素,通过正交实验优选得到最佳膜浓缩工艺。结果古汉养生精口服液最优纳滤浓缩工艺参数为分子截流量:200 Da、压力:0.8 MPa、温度:25℃。结论超滤-纳滤联用技术用于古汉养生精口服液的纯化与浓缩,有效成分的保留率高。Objective To improve the quality of Guhan Yangshengjing oral liquid, reduce the production cost and reduce pollution by ultrafiltration-nanofiltration combined technology. Methods With the retention rate of icariin as indicator, interception molecular weight, pressure, and temperature as factors. The optimum membrane concentration process was optimized by orthogonal experiment.Results The optimum ultrafiltration process were as follows: interception molecular weight was:200 Da, pressure was:0.8 MPa,temperature was:25℃.Conclusion Ultrafiltration-nanofiltration technology was used in the purification and concentration of Guhan Yangshengjing oral liquid. The retention rate of active ingredients is high, the clarity is good.

关 键 词：古汉养生精口服液 超滤 纳滤 淫羊藿苷 

分 类 号：R283[医药卫生—中药学] R284.2[医药卫生—中医学]