可溶性ST2与胸主动脉夹层动脉瘤的相关性研究  

Correlation study between thoracic aortic aneurysm and/or dissection and sST2 in plasma

作　　者：王媛[1] 王雪[1] 姜文溪 王绿娅[1] 任璐 杜杰[1] WANG Yuan;WANG Xue;JIANG Wenxi;WANG Lvya;REN Lu;DU Jie(Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Vessel Disease,The Key Laboratory of Remodeling Related Cardiovascular Disease,Beijing Collaborative Innovation Center for Cardiovascular Disorders,Beijing,100029,China)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所心血管生物研究室

出　　处：《心肺血管病杂志》2019年第5期490-493,共4页Journal of Cardiovascular and Pulmonary Diseases

基　　金：国家重点研发计划精准医学研究重点专项(2017YFC0908400)

摘　　要：目的:探讨可溶性ST2浓度与胸主动脉夹层动脉瘤的关系。方法:回顾性收集首都医科大学附属北京安贞医院胸主动脉夹层动脉瘤住院患者共200例,其中胸主动脉瘤(TAA)患者100例,胸主动脉夹层动脉瘤(TAAD)患者100例。同时年龄匹配后随机抽取同期该院体检中心的无主动脉疾病的健康体检患者100例作为对照。检测血浆可溶性ST2水平,分析TAA组与健康对照组之间和TAA组与TAAD组间可溶性ST2水平的差异。结果:可溶性ST2在TAA组与健康对照组间差异有统计学意义(P<0.01),在TAAD组与TAA组之间,Logistic回归分析得到优势比为2.17(P<0.01)。结论:可溶性ST2水平升高与胸主动脉夹层动脉瘤发生有关。Objective:To investigate the relationship between soluble ST2(sST2)concentration and thoracic aortic aneurysm and/or dissection.Methods:A total of 200 inpatients with thoracic aortic aneurysm and/or dissection in Anzhen hospital affiliated to capital medical university were retrospectively collected,including 100 patients with thoracic aortic aneurysm(TAA)and 100 patients with thoracic aortic aneurysm and/or dissection(TAAD).At the same time,100 healthy patients without aortic disease in the physical examination center of the hospital at the same period were randomly selected after age stratification as the control group.Plasma sST2 level was detected by Elisa kits and analyzed by SPSS and Stata software.Results:There was a significant difference between the TAAD group and the healthy control group in sST2 level(P<0.01),and the odds ratio was 2.17(P<0.01)in the logistic regression analysis.Conclusions:The increase of soluble ST2 level is related to the occurrence of TAAD.

关 键 词：胸主动脉瘤 主动脉夹层动脉瘤 可溶性ST2 

分 类 号：R54[医药卫生—心血管疾病]