经皮电刺激足三里对子痫前期大鼠胆碱能抗炎通路的影响  

Effect of PET on Cholinergic Anti-inflammatory Pathways in Preeclampsia Rats

作　　者：颜学滔[1] 郑文忠[1] 程晓莉[1] 陈虎[1] 袁小芳[1] 王喜文[1] Yan Xuetao;Zheng Wenzhong;Cheng Xiaoli;Chen Hu;Yuan Xiaofang;Wang Xiwen(Department of Anesthesiology,Bao′an Maternal and Child Health Hospital,Shenzhen 518101,China)

机构地区：[1]深圳市宝安区妇幼保健院麻醉科

出　　处：《湖北民族学院学报（医学版）》2019年第2期7-9,14,共4页Journal of Hubei Minzu University(Medical Edition)

基　　金：深圳市卫计委2016科研立项(201601063)

摘　　要：目的探讨子痫前期(PE)可能的发生机制以及经皮电刺激足三里对PE大鼠胆碱能抗炎通路的影响。方法通过观察正常妊娠大鼠、PE大鼠以及电刺足三里PE大鼠体内炎症因子的变化来观察胆碱能抗炎通路的作用。结果PE大鼠分娩前血压水平明显高于其他各组大鼠(P<0.05);与正常组及电刺激组比较,其它各组血浆TNF-α、IL-2、IL-6炎症因子水平显著升高(P<0.05);而电针刺激足三里PE大鼠组血浆中IL-10水平明显高于PE大鼠组(P<0.05)。电针刺足三里PE大鼠组血浆中乙酰胆碱(Ach)水平明显高于其他各组大鼠(P<0.05)。结论PE的发生与母胎免疫失衡或破坏有关,而电针足三里能阻断PE大鼠体内炎症反应,其发生可能与激活体内胆碱能抗炎通路有关。Objective To investigate the effect of PET on cholinergic anti-inflammatory pathways in preeclampsia rats. Methods The effects of cholinergic anti-inflammatory pathways were observed by the changes of inflammatory factors in normal pregnancy rats,preeclampsia rats and electrical stimulation Zusanli(ST36) pre-eclampsia rats. Results Compared with other groups,the pre-delivery blood pressure of rats with preeclampsia was higher than that of other groups ( P <0.05).Compared with preeclampsia group rats,the levels of inflammation of TNF-α,IL-2,IL-6 in plasma were significantly higher than that of rats with normal pregnancy and rats with acupuncture in the pre-eclampsia group.However,the plasma level of IL-10 was higher than that of preeclampsia rats ( P <0.05) in the group of acupuncture of Zusanli preeclampsia.Compared with other groups,the plasma levels of acetylcholine (Ach) in rats with acupuncture in preeclampsia were higher than those of other groups ( P <0.05). Conclusion The occurrence of preeclampsia is related to maternal immunity imbalance or destruction, while electroacupuncture can block the inflammatory response in rats during preeclampsia,which may be related to activating cholinergic anti-inflammatory pathways.

关 键 词：子痫前期 电刺激 足三里 胆碱能抗炎通路 

分 类 号：R714.244[医药卫生—妇产科学]