脂肪组织促进伤口愈合的研究进展  

Research progress in adipose tissue promoted wound healing

作　　者：伍月 李昆[2] 张岩[1] 董佳 于湄[1] 田卫东[1] WU Yue;LI Kun;ZHANG Yan;DONG Jia;YU Mei;TIAN Weidong(National Engineering Laboratory for Oral Regenerative Medicine,West China School of Stomatology,Sichuan University,ChengduSichuan,610041,P.R.China;Department of Oral&Maxillofacial Surgery,Xiangya Stomatological Hospital&School of Stomatology,Central South University,Changsha Hunan,410006,P.R.China)

机构地区：[1]四川大学华西口腔医(学)院口腔再生医学国家地方联合工程实验室,成都610041 [2]中南大学湘雅口腔医(学)院口腔颌面外科,长沙410006

出　　处：《中国修复重建外科杂志》2019年第6期756-761,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家重点研发计划资助项目(2017YFA0104800);国家自然科学基金资助项目(81800952)~~

摘　　要：目的总结脂肪组织促进伤口愈合的研究进展,并分析其临床应用前景。方法查阅近年来国内外有关脂肪组织促进伤口愈合的文献,并进行分析和总结。结果脂肪组织促进伤口愈合的研究取得了巨大进展,包括脂肪组织的细胞类型、细胞外基质、旁分泌信号等方面,均进行了深入研究。结论脂肪组织具有来源广泛、获取便捷等优点,在损伤修复和组织再生领域存在巨大潜力。下一步需探讨脂肪组织调控细胞功能及组织再生机制,以加快脂肪组织在伤口愈合领域的临床应用。Objective To summarize recent progress in adipose tissue acting as a more efficient and ideal therapy to facilitate wound repair and evaluate the therapeutic values of adipose tissue. Methods The related literature about adipose tissue for wound healing in recent years was reviewed and analyzed. Results Enormous studies focus on the capacity of adipose tissue to accelerate wound healing including cellular components, extracellular matrix, and paracrine signaling have been investigated. Conclusion Adipose tissue has generated great interest in recent years because of unique advantages such as abundant and accessible source, thriven potential to enhance the regeneration and repair of damaged tissue. However, there is still a need to explore the mechanism that adipose tissue regulates cellular function and tissue regeneration in order to facilitate clinical application of adipose tissue in wound healing.

关 键 词：脂肪组织 细胞外基质 旁分泌 伤口愈合 

分 类 号：R62[医药卫生—整形外科]