甲状腺疾病的代谢组学研究现状  

Research status of metabolomics in thyroid diseases

作　　者：张玉洁[1] 孟召伟[2] 章明放[3] 宋丽丽[4] 李宁[2] Zhang Yujie;Meng Zhaowei;Zhang Mingfang;Song Lili;Li Ning(Department of Pathology,the General Hospital,Tianjin Medical University,Tianjin 300052,China;Department of Unclear Medicine,the General Hospital,Tianjin Medical University,Tianjin 300052,China;Department of Pathology,Tianjin First Central Hospital,Tianjin 300192,China;College of Traditional Chinese Medicine,Tianjin University of Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津医科大学总医院病理科,300052 [2]天津医科大学总医院核医学科,300052 [3]天津市第一中心医院病理科,300192 [4]天津中医药大学中药学院,300193

出　　处：《国际内分泌代谢杂志》2019年第3期173-177,共5页International Journal of Endocrinology and Metabolism

摘　　要：代谢组学作为继基因组学、转录组学、蛋白组学之后的又一新兴学科,是系统生物学的一个重要部分。代谢组学是对生物体在病理生理刺激下产生的代谢产物的动态分析,反映了生物系统整体功能或状态的最终结果。运用代谢组学的方法对甲状腺疾病的不同样本进行代谢物的变化分析,并结合相关基因和蛋白质的研究方法,对揭示甲状腺疾病的发生机制、提供准确诊断依据以及有效判断预后有着至关重要的意义。Metabolomics is an important component of systems biology as a new subject after genomics, transcriptomics and proteomics. Metabolomics is a dynamic analysis of the metabolites produced by organisms under pathological and physiological stimulation, which reflects the final result of the whole function or state of biological system. Using metabolomics to analyze the metabolites changes in different samples of thyroid diseases and combining the research methods for related genes and proteins, is of vital significance to reveal the mechanism, provide accurate diagnostic basis and effectively judge the prognosis.

关 键 词：代谢组学 甲状腺癌 甲状腺功能异常 桥本甲状腺炎 

分 类 号：R581[医药卫生—内分泌]