牛奶菜水提物对中华眼镜蛇毒神经毒性的抑制作用  

The Inhibition of Aqueous Extract from Marsdenia sinensis on the Neurotoxicity of Naja atra Venom

作　　者：罗聪 和七一 谭佳 曹雪婷 聂学奎 熊艳 王萍 黄达春 余晓东 LUO Cong;HE Qiyi;TAN Jia;CAO Xueting;NIE Xuekui;XIONG Yan;WANG Ping;HUANG Dachun;YU Xiaodong(Chongqing Key Laboratory of Animal Biology,Collaborative Innovation Center of Venomous Snake Man-Culture and Deep Processing,Engineering Research Center of Active Substance and Biotechnology(Ministry of Education),Chongqing Engineering Research Center of Active Substance,College of Life Sciences,Chongqing Normal University,Chongqing 401331,China)

机构地区：[1]重庆师范大学生命科学学院重庆市生物活性物质工程研究中心教育部活性物质生物技术工程研究中心毒蛇养殖与深加工协同创新中心重庆市动物生物学重点实验室

出　　处：《重庆师范大学学报（自然科学版）》2019年第3期111-117,共7页Journal of Chongqing Normal University:Natural Science

基　　金：重庆市自然科学基金(No.cstc2017chmsxdny0246;No.cstc2015shmszx120052)

摘　　要：【目的】考察牛奶菜(Marsdenia sinensis)水提物对中华眼镜蛇(Naja atra)毒神经毒性的抑制作用。【方法】利用四通道离体组织灌流系统和昆明小鼠(Mus musculus)离体回肠标本检测牛奶菜水提物对中华眼镜蛇毒神经毒性的抑制、即时中和与恢复作用。【结果】牛奶菜水提物对中华眼镜蛇毒神经毒性有一定抑制作用。【结论】研究结果揭示了牛奶菜用于治疗中华眼镜蛇咬伤的有效性,为后续开发抗蛇毒药物奠定了基础。[Purposes]To investigate the inhibitory effect of Marsdenia sinensis aqueous extract on the neurotoxicity of Naja atra venom.[Methods]In vitro using mouse isolated ileum fragments to detect the inhibitions,immediate neutralizations and recovery effects of the aqueous extract from Chinese herb M.sinensis against the neurotoxicity of N.atravenom.[Findings]The aqueous extract from Chinese herb M.sinensis has a certain inhibitory effect against the neurotoxicity of N.atra venom.[Conclusions]The study revealed there is some effectiveness of Chinese herb M.sinensis used for the treatment of N.atra bites,also laid a base for the future studying on the anti-venom medicines.

关 键 词：牛奶菜 中华眼镜蛇毒 颤动 离体回肠 

分 类 号：Q599[生物学—生物化学]