血清胱抑素C、尿肾损伤分子1与造影剂肾病的相关性及临床意义  

Correlation and Clinical Significance of Serum Cystatin C, Urinary Kidney Injury Molecule 1 with Contrast-Induced Nephropathy

作　　者：扆恒亮[1] 孙誉 刘君[1] 杨大浩 YI Heng-liang;SUN Yu;LIU Jun(Second People's hospital of Guangdong Province,Guangzhou Guangdong 510317)

机构地区：[1]广东省第二人民医院,广东广州510317 [2]中国医学科学院阜外医院深圳医院,广东深圳518021

出　　处：《医学临床研究》2019年第5期917-918,921,共3页Journal of Clinical Research

摘　　要：【目的】探讨血清胱抑素C(Cys-C)、尿肾损伤分子1(Kim-1)与造影剂肾病(CIN)的相关性及临床意义。【方法】本院收治的CIN患者43例作为观察组,选取同时期来本院健康检查的健康人群43例作为对照组,比较两组对象的Cys-C以及Kim-1等因子表达水平的差异,并观察患者临床特征与生化指标之间的相关性。【结果】观察组患者Cys-C,Kim-1水平明显高于对照组,且差异有显著性(P<0.05);CIN患者Cys-C以及Kim-1水平随着病情的严重程度逐渐升高,重度患者的Cys-C及Kim-1水平明显高于CIN中度和轻度患者(P<0.05),CIN中度患者Cys-C以及Kim-1水平高于轻度患者,且差异均有显著性(P<0.05)。相关性分析显示性别、年龄、造影剂用量、Cys-C以及Kim-1水平与CIN的发生率有明显的相关性(P<0.05)。【结论】Cys-C、Kim-1指标与CIN患者之间有着较为密切的联系,能反映患者疾病的严重程度,能为患者早期疾病的诊治提供可靠的依据。【Objective】To investigate the correlation and clinical significance of serum cystatin C(Cys-C), urinary kidney injury molecule 1 (Kim-1) with contrast-induced nephropathy(CIN).【Methods】A total of 43 patients with CIN admitted to our hospital were enrolled in the observation group, while 43 cases of healthy volunteers in the same period were selected as the control group. The differences in the expression levels of Cys-C and Kim-1 were compared between the two groups, and the correlation between clinical features and biochemical indicators was observed.【Results】In terms of related factor levels, the levels of Cys-C and Kim-1 in the observation group were significantly higher than those in the control group (P<0.05). The levels of Cys-C and Kim-1 in patients with CIN gradually increased with the severity of the disease. The levels of Cys-C and Kim-1 in severe patients were significantly higher than those in moderate and mild CIN patients (P<0.05). The levels of Cys-C and Kim-1 were higher in patients than in mild patients, and the differences were significant (P<0.05). Correlation analysis showed that gender, age, contrast agent dosage, Kim-1and Cys-C levels were were significantly correlated with the incidence of CIN (P<0.05).【Conclusion】 Indicators such as Cys-C and Kim-1 are closely related to patients with CIN , which can reflect the severity of the disease and provide reliable evidence for the diagnosis and treatment of early disease.

关 键 词：肾疾病/化学诱导 造影剂/副作用 半胱氨酸蛋白酶抑制剂 

分 类 号：R692[医药卫生—泌尿科学]