隐匿性HBV感染献血者随访复查及归队可能性探讨  

Follow-up study of blood donors with occult Hepatitis B virus infection and feasibility analysis of the reentry

作　　者：欧山海 张雅丽 杨寿琼 裴斌 宋秀宇 OU ShanHai;ZHANG YaLi;YANG Shouqiong;PEI Bin;SONG Xiuyu(Xiamen Blood Center,Xiamen 361004,China)

机构地区：[1]厦门市中心血站,福建厦门361004

出　　处：《中国输血杂志》2019年第4期366-370,共5页Chinese Journal of Blood Transfusion

基　　金：福建省医学创新课题(2016-CXB-15);福建省卫生计生委青年科研课题(2015-2-58)

摘　　要：目的了解隐匿性HBV感染献血者的转归情况及回归献血的可能性。方法对部分隐匿性HBV感染献血者进行随访,复检HBsAg、HBV DNA及抗-HBs和抗-HBc等。结果共有51名OBI献血者完成随访复检,平均年龄为41.68±7.71岁;其中34名出现HBV DNA转阴(66.7%),平均年龄(34.88±9.05)岁;17名献血者随访时持续HBV DNA阳性,平均年龄(44.88±4.81)岁,P<0.05。男性OBI献血者出现HBV DNA转阴的比例(64.3%)与女性(77.8%)的差异无统计学意义;随访前体内是否抗-HBs阳性与随访时是否HBV DNA转阴没有必然联系。所有随访的献血者HBsAg持续阴性、ALT正常且无不适症状。结论 OBI献血者在随访的病程中存在较高比例的转阴率,是否可以归队献血需要经过严格的复检。Objective To study the outcome of blood donors with occult hepatitis B virus infection(OBI)and discuss the feasibility of their reentry to blood donation.Methods A partial of OBI blood donors from our center were tracked,and their HBsAg,HBV DNA,anti-HBs and anti-HBc was re-tested.Results A total of 51 OBI donors(median 41.68 years old)were successfully followed-up.Among them,34(median 34.87 years old)were converted to HBV DNA negative(66.7%);17 donors(median 44.88 years old)remained the same HBV DNA positive state.There was a significant difference in ages between the above groups(P<0.05).The proportion of HBV DNA converted into negative in male OBI donors(64.3%)is lower than that in female(77.8%),but with no statistically significant difference(P>0.05).Anti-HBs positive or not before follow-up has no direct correlation with the HBV DNA negative conversion.All tracked donors retained HBsAg negative with routine ALT normal,and no symptoms of discomfort were complained.Conclusion A high proportion of OBI blood donors could recover spontaneously after deferral.A strict track detection for those donors is suggested,then according to test results,donors can be either eliminated or retained.

关 键 词：隐匿性乙肝感染 核酸检测 随访 

分 类 号：R373.21[医药卫生—病原生物学] R193.3[医药卫生—基础医学]