Knoevenagel法合成3,4-二甲氧基肉桂酸及其工艺优化  

Synthesis of 3,4-dimethoxycinnamic Acid by Knoevenagel Method and Its Process Optimization

作　　者：翁建清 周筱倩 张赛婷 伍智敏 梅安江 董术播 柯中炉[1] Weng Jianqing;Zhou Xiaoqian;Zhang Saiting;Wu Zhimin;Mei Anjiang;Dong Shubo;Ke Zhonglu(Taizhou Technical College,Biopharmaceutical R&D Center,Taizhou 318000,China)

机构地区：[1]台州职业技术学院生化制药研发中心,浙江台州318000

出　　处：《山东化工》2019年第9期83-84,91,共3页Shandong Chemical Industry

基　　金：台州市大学生科技创新项目(No 2017DKC08)

摘　　要：以Knoevenagel法合成3,4-二甲氧基肉桂酸。详细考察了催化剂种类和用量、反应物料配比、反应温度、反应时间等因素对反应结果的影响,综合分析得到较佳合成工艺条件。在n(丙二酸)/n(3,4-二甲氧基苯甲醛)为1.2、n(哌啶)/n(3,4-二甲氧基苯甲醛)为0.3、反应温度90℃、反应时间2.5 h的条件下,得到精制后产品收率为76.5%、纯度为99.2%。且具有条件温和、反应温度低、操作简便、产品收率和质量高等优点。The 3,4-dimethoxycinnamic acid was synthesized by the Knoevenagel method. The effects of catalyst type and dosage,reaction material ratio,reaction temperature and reaction time on the reaction results were investigated in detail. The comprehensive synthesis conditions were obtained by comprehensive analysis. In n(malonic acid)/n(3,4-dimethoxybenzaldehyde) is 1.2,n(piperidin)/n(3,4-dimethoxybenzaldehyde) is 0.3,the reaction temperature is 90 ℃ Under the condition of a reaction time of 2.5 h,the yield of the purified product was 76.5%,and the purity was 99.2%. The invention has the advantages of mild conditions,low reaction temperature,simple operation,high product yield and high quality.

关 键 词：Knoevenagel法 3 4-二甲氧基肉桂酸 合成 

分 类 号：TQ245.2[化学工程—有机化工]