北京地区尘螨过敏患者特异性IgE水平分析  

An Analysis of the Specific IgE Level for Patients Allergic to Dust Mite in Beijing Area

作　　者：孔瑞 王学艳 KONG Rui;WANG Xue-yan(Allergology Department of Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属北京世纪坛医院变态反应科

出　　处：《标记免疫分析与临床》2019年第6期901-904,共4页Labeled Immunoassays and Clinical Medicine

基　　金：北京市2018年度临床医学发展专项“杨帆”计划(编号:ZYLX201826)

摘　　要：目的了解北京地区不同年龄、性别尘螨过敏患者对尘螨敏感性差异。方法本研究采用回顾性横断面研究,纳入我科2016年8月至2017年7月因过敏性疾病就诊、户尘螨或粉尘螨至少一项sIgE阳性患者318例。分别比较户尘螨及粉尘螨sIgE水平差异以及不同性别、年龄患者尘螨sIgE水平差异。结果两种尘螨sIgE水平差异无统计学意义(P=0.336)。男性患者血清特异性IgE(sIgE)平均水平明显高于女性患者(P=0.009),其中男性特重度过敏患者所占比例明显高于女性(P<0.001),但女性中度过敏患者所占比例明显高于男性(P=0.01)。年龄与抗体水平呈明显负相关(R=-0.217,P<0.001)。婴幼儿、儿童、少年组中特重度过敏患者所占比例最高,分别为各自组的42.3%、31.5%、38.1%。儿童及少年特重度过敏患者中,男性患者所占比例明显高于女性(P=0.04,P=0.01)。结论户尘螨及粉尘螨过敏常同时存在,且过敏严重程度相当。尘螨过敏原敏感程度与年龄及性别明确相关。Objective The purpose of this study was to explore dust mite sensitization feature across different ages and genders. Methods 318 patients with typical allergic symptoms were enrolled in this retrospective cross-sectional study from August,2016 to July,2017.All participants were sensitized to either Dermatophagoides pteronyssinus(Dp)or Dermatophagoides farina(Df)in the specific IgE(sIgE)tests.The differences of Dp and Df in sIgE levels,age and gender of the study subjects were compared. Results No significant differences were observed in sIgE levels between Dp and Df( P =0.336).sIgE level was significantly higher in male than in female( P =0.009).The rate of severe HDM allergy patients in male was higher than in female,while the rate of moderate allergy patients in male was lower than in female( P <0.001, P =0.01,respectively).sIgE level was negatively correlated with age( R =-0.217, P =0.001).The highest severe HDM allergy rate was observed in the infants group(42.3%),followed by the adolescents group(38.1%)and the children group(31.5%).In the children and adolescents severe HDM allergy groups,a male predominance was observed( P =0.04, P =0.01,respectively). Conclusion An extensive homology is found between Dp and Df.The sensitization severity of HDM is correlated with age and gender.

关 键 词：过敏 户尘螨 粉尘螨 特异性IGE 

分 类 号：R593.1[医药卫生—内科学] R446.6[医药卫生—临床医学]