Ski在脊髓损伤后胶质瘢痕形成中的作用及机制研究进展  

Role and Mechanism of Ski in Glial Scar Formation post Spinal Cord Injury(review)

作　　者：向高 刘开鑫 巩朝阳 杨亮 张海鸿[1] XIANG Gao;LIU Kai-xin;GONG Chao-yang;YANG Liang;ZHANG Hai-hong(Department of Orthopedics,the Second Clinical Medical College of Lanzhou University,Lanzhou,Gansu 730030,China;Lanzhou University Key Laboratory of Orthopedics of Gansu Province,Lanzhou,Gansu 730030,China)

机构地区：[1]兰州大学第二医院骨科,甘肃兰州市730030 [2]兰州大学甘肃省骨关节疾病研究重点实验室,甘肃兰州市730030

出　　处：《中国康复理论与实践》2019年第6期630-633,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：甘肃省自然科学基金项目(No.17JR5RA238);兰州大学第二医院"萃英科技创新"基金项目(No.CY2017-MS06)~~

摘　　要：Ski是一种进化保守蛋白,广泛参与并调节不同物种中多种细胞的增殖、分化、转化及肿瘤进展等过程。在脊髓损伤中,星形胶质细胞的活化及反应性星形胶质增生是影响脊髓损伤后胶质瘢痕形成的重要因素。Ski在脊髓损伤后高表达,并通过转化生长因子-β、促分裂原活化蛋白激酶等信号通路作用于星形胶质细胞,调控其活化、增殖、迁移以及胶质瘢痕形成等过程,为脊髓损伤的治疗提供新的治疗方向。Ski is an evolutionary conserved protein,which is involved in diverse cellular processes such as proliferation,differentiation, transformation and tumor progression.In spinal cord injury,the activation of astrocytes and reactive astrocyte hyperplasia are important factors affecting the formation of glial scar after spinal cord injury.Ski is highly expressed after spinal cord injury,and acts on astrocytes through transforming growth factor-beta,mitogen-activated protein kinase and other signaling pathways,and regulates their activation,proliferation,migration and glial scar formation,providing a new therapeutic direction for the treatment of spinal cord injury.

关 键 词：脊髓损伤 胶质瘢痕 SKI 机制 综述 

分 类 号：R651.2[医药卫生—外科学]