皮肤致敏试验替代方法研究进展  

Research progress on alternative methods for skin sensitization tests

作　　者：梅承翰 谭红 杨鸿波 陈蓓蓓 刘师卜[2] 刘婷[2] MEI Cheng-han;TAN Hong;YANG Hong-bo;CHEN Bei-bei;LIU Shi-bu;LIU Ting(Guizhou Academy of Testing and Analysis, Guiyang, Guizhou 550016, China;National Institutes for Food and Drug Control, Beijing 100050, China;Guizhou JAD Technology Co., LTD, Guiyang, Guizhou 550016, China)

机构地区：[1]贵州省分析测试研究院,贵州贵阳550016 [2]中国食品药品检定研究院,北京100050 [3]贵州健安德科技有限公司,贵州贵阳550016

出　　处：《日用化学工业》2019年第6期393-397,402,共6页China Surfactant Detergent & Cosmetics

基　　金：中国食品药品检定研究院中青年发展研究基金课题(2017C6);贵州省科技计划项目(黔科合平台人才[2016]5709);贵阳国家高新技术产业开发区管理委员会科技计划项目(GXYF-2017-001)

摘　　要：概述并比较分析了直接肽反应试验(DPRA)、小鼠局部淋巴结试验(LLNA)、KerationSens^TM、人细胞系激发试验(h-CLAT)和重组人表皮致敏试验等皮肤致敏试验替代方法,并重点介绍了各替代方法的整合研究情况,提出了皮肤致敏试验替代方法的发展前景。In the present study, skin sensitization alternative methods, such as direct peptide reactivity assay(DPRA), local lymph node assay(LLNA), KerationSens^TM, human cell line activation test(h-CLAT)and reconstructed human epidermis model(RHE model)sensitization test, were summarized, analyzed and compared. The integration of these alternative methods was introduced, and the development prospects of alternative methods for skin sensitization test were prospected.

关 键 词：皮肤致敏 替代方法 进展 整合 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]