亚低温对实验动物出血性脑卒中结局影响的系统评价与Meta分析  

Effect of mild hypothermia on outcomes of hemorrhagic stroke in experimental animals:a systematic review and Meta-analysis

作　　者：王文阳[1] 林清国[1] 刘东辉 杨修[1] 杨武双[1] WANG Wenyang;LIN Qingguo;LIU Donghui;YANG Xiu;YANG Wushuang(Department of Neurosurgery,Xiamen Hospital of Traditional Chinese Medicine,Xiamen,Fujian 361000,China)

机构地区：[1]福建省厦门市中医院神经外科

出　　处：《重庆医学》2019年第12期2076-2080,2086,共6页Chongqing medicine

基　　金：福建省厦门市科研计划项目(3502Z20154055)

摘　　要：目的系统评价亚低温对实验动物出血性脑卒中结局的影响。方法检索PubMed、Embase、Web of Science、Google Scholar以及中国知网、维普数据库、万方数据知识服务平台等中英文数据库中关于亚低温用于出血性脑卒中动物模型的研究,检索时间为建库之日至2018年5月。按纳入与排除标准筛选文献、提取资料和方法学质量评价后,采用STATA12.0软件进行Meta分析。结果共纳入19项研究,其中低温组动物1023只,常温对照组668只。Meta分析结果显示:与常温组相比,亚低温对出血性脑卒中动物脑出血量的影响无统计学意义[SMD=0.28,95%CI(-0.33,0.88),P>0.05],但亚低温可减少出血后脑组织水肿[SMD=-2.16,95%CI(-3.09,-1.22),P<0.05]、减轻血脑屏障损害[SMD=-4.84,95%CI(-7.00,-2.67),P<0.05],并提高实验动物神经功能评分[SMD=1.06,95%CI(0.46,1.66),P<0.05]。结论亚低温对出血性脑卒中动物具有神经保护作用,该作用主要通过减轻脑组织水肿和稳定血脑屏障实现。Objective To systematically evaluate the effects of mild hypothermia on the outcomes of hemorrhagic stroke in experimental animals.Methods English and Chinese databases including PubMed,Embase,Web of Science,Google Scholar,CNKI,VIP,and Wanfang were retrieved for related studies to mild hypothermia hemorrhagic stroke in animal models.The retrieved time was limited from their building to May 2018.After screened in accordance with the established criteria for inclusion or exclusion,methodologically evaluation,the included data was analyzed for Meta-analysis with STATA 12.0 software.Results A total of 19 studies were included eventually.Among them,1 023 animals were in the mild hypothermia group and 668 animals were in the normal temperature control group.Meta-analysis results showed that compared with the control group,mild hypothermia had no significant effect on the amount of cerebral hemorrhage in hemorrhagic stroke animals [ SMD = 0.28,95% CI (-0.33,0.88), P >0.05],but mild hypothermia could reduce brain edema after hemorrhage [ SMD =-2.16,95% CI (-3.09,-1.22), P <0.05],reduce the damage of blood brain barrier [ SMD =-4.84,95% CI (-7.00,-2.67), P <0.05] and improve the functional score of experimental animals [ SMD =1.06,95% CI (0.46,1.66), P <0.05].Conclusion Mild hypothermia has neuroprotective effects in experimental animals with hemorrhagic stroke which mainly achieved by reducing brain edema and stabilizing blood brain barrier.

关 键 词：亚低温 出血性脑卒中 系统评价 META分析 动物实验 

分 类 号：R651.1[医药卫生—外科学]