超声波下4-甲基-6-苯基-5-乙氧羰基-3,4-二氢嘧啶-2-硫酮的合成研究  

Study on Synthesis of 4-methyl-6-phenyl-5-ethoxycarbonyl-3,4-dihypyrimidine-2-sulfur Ketone under Ultrasonic Irradiation

作　　者：韩小见[1] HAN Xiao-jian(Department of Chemistry,Changzhi University,Changzhi Shanxi,046011,China)

机构地区：[1]长治学院化学系

出　　处：《晋中学院学报》2019年第3期28-32,共5页Journal of Jinzhong University

基　　金：长治学院教改项目:“环保意识在有机化学实验教学中的培养”(JC201816)阶段性成果

摘　　要：超声波辐射下利用Biginelli缩合反应,以苯甲醛、乙酰乙酸乙酯和硫脲为原料,对甲苯磺酸为催化剂合成4-甲基-6-苯基-5-乙氧羰基-3,4-二氢嘧啶-2-硫酮.探究反应物的配比、溶剂种类、反应温度、催化剂用量等因素对产率的影响,得到较佳合成条件:无溶剂,对甲苯磺酸0.50g,温度65℃,原料配比n苯甲醛:n乙酰乙酸乙酯:n硫脲=1.0:1.0:1.0,产率37.7%,并对产物进行了初步表征.Under ultrasonic irradiation,4-methyl-6-phenyl-5-ethoxycarbonyl-3,4-dihypyrimidine-in-2-sulfur ketone was synthesized by Biginelli condensation reaction using benzaldehyde,ethyl acetoacetate and thiourea as raw materials,p-toluenesulfonic acid as catalyst.The optimum reaction conditions of ultrasonic radiation were obtained by exploring the influence of the ratio of raw materials,the kind of solvent,reaction temperature and the amount of catalyst of the reaction on the yield.The result is p-toluenesulfonic acid as a c-atalyst and an amount of 0.5 g,the temperature(65℃),no solvent,ratio of raw materials(1.0︰1.0︰1.0),the yield(37.7%).The production was preliminary characterized.

关 键 词：超声波辐射 比吉内利反应 3 4-二氢嘧啶-2-硫酮 

分 类 号：O626.4[理学—有机化学]