静脉丙种球蛋白治疗不完全川崎病与典型川崎病患儿的疗效  

Efficacy of intravenous gamma globulin in children with incomplete Kawasaki disease and typical Kawasaki disease

作　　者：郑洁华 ZHENG Jiehua(Hexian Memorial Hospital,Panyu District,Guangzhou 511400,China)

机构地区：[1]广州市番禺区何贤纪念医院

出　　处：《中国医药科学》2019年第11期204-206,210,共4页China Medicine And Pharmacy

摘　　要：目的探究典型和不完全川崎病患者均行静脉丙种球蛋白治疗的效果差异性。方法选取2017年1~12月我院收治的60例川崎病患儿为研究对象,根据患儿病变情况进行分组,其中24例典型川崎病患儿为典型组,36例不完全川崎病患儿为不完全组,两组患者均行静脉丙种球蛋白治疗法,应用统计学软件对两组患儿临床症状改善及住院时间进行比较,对两组患儿治疗前后血液检测指标及冠状动脉病变情况进行比较。结果不完全组患儿发热、粘膜充血、皮疹、手足肿胀及淋巴结肿大等临床症状消退时间及住院时间相较于典型组患儿显著更少,数据经比较差异有统计学意义(P <0.05);治疗前两组患儿血小板、白细胞、血沉、C反应蛋白水平等血液检测指标,及冠状动脉病变发生率经比较差异无统计学意义(P> 0.05),治疗后不完全组患儿4项血液检测指标及冠状动脉病变发生率相比典型组显著更低,数据经比较差异有统计学意义(P <0.05)。结论静脉丙种球蛋白对小儿不完全川崎病的疗效显著优于典型川崎病患儿,提示针对典型川崎病患儿需要加大给药剂量,延长给药时间以提升其临床疗效,同时针对不完全川崎病患儿的治疗可采取本次研究所用疗法,并可用于临床推广。Objective To explore the difference in the efficacy of intravenous gamma globulin therapy in children with typical and incomplete Kawasaki disease. Methods 60 children with Kawasaki disease admitted to our hospital from January to December 2017 were selected as study objects,they were divided into groups according to the condition changes of the disease,24 cases of typical Kawasaki disease were selected as typical group and 36 cases of incomplete Kawasaki disease as incomplete group.Both the two groups were treated with intravenous gamma globulin.Clinical symptom improvement and hospitalization time between two groups were compared by statistical software,the blood test indexes and condition changes of coronary artery disease between the two groups before and after treatment were compared. Results The clinical symptoms such as fever,mucosal congestion,rash,hand and foot swelling and lymphadenectasis disappeared time and hospitalization time of incomplete group were significantly less than the typical group,with statistically significant(P < 0.05).Before treatment,there was no significant difference in blood test indexes such as platelet,leucocyte,erythrocyte sedimentation rate,C-reactive protein level and incidence of coronary artery disease between the two groups(P > 0.05).After treatment,the incidence of the four blood test indexes and coronary artery disease in the incomplete group was significantly lower than the typical group, the difference was statistically significant(P < 0.05). Conclusion The effect of intravenous gamma globulin on children with incomplete Kawasaki disease is significantly better than that of children with Kawasaki disease,suggesting that children with typical Kawasaki disease need to increase the dose, prolong the time of administration to improve their clinical efficacy.The treatment of this study can be used for the children with incomplete Kawasaki disease and can be used for clinical promotion.

关 键 词：静脉丙种球蛋白 不完全川崎病 典型川崎病 冠状动脉病变 

分 类 号：R725.4[医药卫生—儿科]