杀菌剂环丙唑醇的合成  

Synthesis of Fungicide Cyproconazole

作　　者：王世银 WANG Shi-yin(Guangdong Greatchem Chemicals Co., Ltd., Qingyuan, Guangdong 513052, China)

机构地区：[1]广东广康生化科技股份有限公司,广东清远513052

出　　处：《浙江化工》2019年第6期10-11,共2页Zhejiang Chemical Industry

摘　　要：以1-(4-氯苯基)-2-环丙基-1-丙酮为起始原料,经硫叶立德反应生成环氧化合物,再与水合肼反应,最后与N-二氯甲基甲脒反应合成环丙唑醇,此方法避免了异构体1,3,4-三氮唑的生成,简化了后处理,含量大于98%,总收率为79.1%(以1-(4-氯苯基)-2-环丙基-1-丙酮计)。1-(4-chlorophenyl)-2-cyclopropyl-1-propanone was used as the starting material to form an epoxy compound by sulfur ylide reaction, which was then reacted with hydrazine hydrate and finally with N-dichloromethyl. Synthesis of cyproconazole by the reaction of formazan, this method avoided the formation of isomer 1,3,4-triazole, simplifies the post-treatment, the content was more than 98%, the total yield was 79.1%(to 1-(4)-Chlorophenyl)-2-cyclopropyl-1-propanone).

关 键 词：杀菌剂 环丙唑醇 水合肼 N-二氯甲基甲脒 合成 

分 类 号：TQ455.4[化学工程—农药化工]