干细胞组织工程技术辅助下颌牵张成骨的研究与进展  

Research progress in stem cell-based tissue engineering technology assisting mandibular distraction osteogenesis

作　　者：韩志琪 蒋伟东 周诺[1] Han Zhiqi;Jiang Weidong;Zhou Nuo(Department of Oral and Maxillofacial Surgery, Stomatology Hospital ofGuangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China)

机构地区：[1]广西医科大学附属口腔医院口腔颌面外科

出　　处：《中国组织工程研究》2019年第25期4037-4043,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81670970),项目负责人:周诺~~

摘　　要：背景:下颌牵张成骨在临床取得重大反响以来,大量学者致力于增强成骨、缩短疗程的研究,其中干细胞移植作为当前的热点备受关注。目的:总结目前使用干细胞组织工程技术辅助下颌牵张成骨的进展与不足。方法:遵循PRISMA指南,由第一作者以"牵张成骨,下颌骨,下颌,干细胞"为中文检索词,以"distraction osteogenesis,mandibular,mandible,stemcells"为英文检索词,对PubMed、WOS、CNKI、万方等数据库分别进行检索,对文献中的动物模型、干细胞种类及移植方式等进行统计并制表做简要介绍。结果与结论:从目标文献中严格按照标准筛选出51篇文献进行分析、总结。文献中干细胞移植的时机、方式及种类等有着很大的差异。大量动物实验结果证实干细胞组织工程技术可以增强下颌牵张成骨中骨与血管的再生。探讨干细胞组织工程技术辅助下颌牵张成骨中干细胞的选择与应用,不仅能为将来的治疗提供思路,还能为接下来的临床试验打下基础。BACKGROUND: Since mandibular distraction osteogenesis has achieved significant repercussions in clinical practice, many scholars have been working on studies that enhancing osteogenesis and shortening the course of treatment. Among them, stem cell transplantation has attracted much attention as a hotspot.OBJECTIVE: To summarize the current progress and deficiency of stem cell-based tissue engineering technology assisting mandibular distraction osteogenesis.METHODS: Following the PRISMA guidelines, a computer-based search of PubMed, WOS, CNKI and WanFang databases was performed by the first author for relevant articles with the keywords of "distraction osteogenesis,mandibular, mandible, stem cells" in English and Chinese, respectively. Animal models, types of stem cells and routes of transplantation in the selected literature were extracted and counted up. The results were tabulated and introduced briefly.RESULTS AND CONCLUSION: Fifty-one articles were strictly selected as per the eligibility criteria, analyzed and summarized. In the selected literature, the timing, methods and types of stem cell transplantation vary greatly. The majority of animal experimental studies have confirmed that stem cell-based tissue engineering technology can enhance bone and blood vessel regeneration in mandibular distraction osteogenesis. Explorations on the selection and application of stem cells in mandibular distraction osteogenesis assisted by stem cell-based tissue engineering technology cannot only provide ideas for future treatment, but also lay the foundation for clinical trials.

关 键 词：下颌牵张成骨 组织工程 干细胞 骨再生 血管再生 干细胞移植 国家自然科学基金 

分 类 号：R459.9[医药卫生—治疗学] R394.2[医药卫生—临床医学]