基于文献探讨中药汤剂复方内服治疗下焦湿热型尿石症的用药规律  

Discuss on Medication Rules of Compound Recipe in Traditional Chinese Medicine Decoction on Urinary Calculus with Syndrome of Dampness-Heat in Lower Jiao Based on Literatures

作　　者：王定国 白强民 张明强 王立春 蔡阳恺 林煦垚 秦国政[2] WANG Dingguo;BAI Qiangmin;ZHANG Minqiang;WANG Lichun;CAI Yangkai;LIN Xuyao;QIN Guozheng(Yunnan University of Traditional Chinese Medicine, Kunming 650500, China;First Affiliated Hospital of Yunnan College of Traditional Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming 650021, China;Anhui University of Chinese Medicine, Hefei 230038, China)

机构地区：[1]云南中医学院,云南昆明650500 [2]云南中医学院第一附属医院/云南省中医医院,云南昆明650021 [3]安徽中医药大学,安徽合肥230038

出　　处：《云南中医学院学报》2018年第5期38-45,共8页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家中医药“十一五”重点学科中医男科学建设项目[国中医药发(2009)30号];云南省卫生科技计划重点项目(2017NS149)

摘　　要：目的基于文献探讨中药汤剂复方内服治疗下焦湿热型尿石症的用药规律和特点,为尿石症的中医临床治疗提供参考和借鉴。方法检索近30年相关文献,将最终筛选出的25篇文献中的中药归类,并分别查出其药性、味、功效及归经,运用Excel、Spss 20.0、Weka 3.8、Cytoscape 3.6.1对文献数据进行统计分析。结果统计分析发现,治疗本病出现频数最高的药物为金钱草、海金沙、鸡内金,占总频次的80%以上,并从高频药物之间的关联规则中挖掘出最常用药对和药组搭配;从功效角度以利水渗湿药为主,其次是补虚药、活血化瘀药,三者累计占总频次的56.56%;从药性角度主要以寒性为主,其次是平性、温性药物,三者累计占药性总频次的66.88%;从药味角度以甘味为最,其次是苦、淡味药,三者累计占药味总频次的61.39%;从药物归经角度以归膀胱经药物为最,其次是归肝、肾经药物,三者累计占归经总频次的32.14%。结论从用药规律中体现常用药物紧扣其病因病机,以膀胱肝肾功能失调为本,临床上多选用补益脾肾、清利湿热、活血祛瘀、通淋排石之法治疗本病。文献数据挖掘对于临床用药的规律及特点的整理和归纳具有实用价值。Objective Discuss on Medication Rules and characteristics of Compound Recipe in Traditional Chinese Medicine Decoction on Urinary Calculus with Syndrome of Dampness-Heat in Lower Jiao Based on Literatures, and to provide reference for the clinical treatment of diabetic urolithiasis of traditional Chinese medicine. Methods Relevant literatures in the past 30 years were searched and 25 Chinese medicines were classified. The medicinal properties, flavors, efficacy and meridians of Chinese medicines were identified. The literature data were analyzed by Excel, Spss 20.0, Weka 3.8 and Cytoscape 3.6.1. Results Statistical analysis showed that the most frequently used drugs for the treatment of this disease were Jinqiancao, Haijinsha and Jineijin, which occupied more than 80% of the prescription frequency, and the most commonly used drug pairs and drug group combinations were excavated from the association rules between high-frequency drugs. From the perspective of efficacy, the main drugs were diuretics for eliminating dampness, followed by tonic medicine, drug for invigorating blood circulation and eliminating stasis, the total frequency was 56.56%. From the perspective of medicinal properties of traditional Chinese Medicine, coolness was dominant, followed by neutral and warmth, which accounted for 66.88% of the total frequency of medicinal properties. From the perspective of medicinal taste, sweetness was the most important, followed by bitter and light taste, which accounted for 61.39% of the total frequency of medicinal taste. From the perspective of medicinal meridian, bladder meridian drugs were the most important. Secondly, the liver meridian and kidney meridian drugs accounted for 32.14% of the total frequency of the three meridian. Conclusion From the law of medication, we can see that the common medicines are closely related to their etiology and pathogenesis, and the dysfunction of bladder, liver and kidney is the basis. In clinic, the methods of invigorating spleen and kidney, clearing dampness and heat, ac

关 键 词：尿石症 下焦湿热型 中药 治疗 用药规律 

分 类 号：R269[医药卫生—中西医结合]